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10.3390/cells10061424

http://scihub22266oqcxt.onion/10.3390/cells10061424
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suck abstract from ncbi


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pmid34200500      Cells 2021 ; 10 (6): ä
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  • How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System #MMPMID34200500
  • Sajidah ES; Lim K; Wong RW
  • Cells 2021[Jun]; 10 (6): ä PMID34200500show ga
  • The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment.
  • |*Virus Physiological Phenomena[MESH]
  • |Active Transport, Cell Nucleus/physiology[MESH]
  • |COVID-19/metabolism/virology[MESH]
  • |Cell Nucleus/*metabolism/*virology[MESH]
  • |Host-Pathogen Interactions/physiology[MESH]
  • |Humans[MESH]
  • |Nucleocytoplasmic Transport Proteins/metabolism[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Virus Internalization[MESH]
  • |Virus Replication/*physiology[MESH]


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