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10.3390/ijms22116151 http://scihub22266oqcxt.onion/10.3390/ijms22116151 34200325!8201243!34200325     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34200325.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2021 ; 22 (11): ä Nephropedia Template TP {{tp|p=34200325|t=2021. Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors |pdf=|usr=}}{{34200325}} gab.com Text Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34200325 #FOAvip The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called persistent post-COVID-19 syndrome (PPCS) is a common finding. In COVID-19 survivors, PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. In this study, a cohort of 117 COVID-19 survivors (post-COVID-19) and 144 non-infected volunteers (COVID-19-free) was analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. The results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 +/- 7.29 years (+5.25 years above the range of normality) compared with 3.68 +/- 8.17 years for the COVID-19-free population (p < 0.0001). A significant telomere shortening parallels this finding in the post-COVID-19 cohort compared with COVID-19-free subjects (p < 0.0001). Additionally, ACE2 expression was decreased in post-COVID-19 patients, compared with the COVID-19-free population, while DPP-4 did not change. In light of these observations, we hypothesize that some epigenetic alterations are associated with the post-COVID-19 condition, particularly in younger patients (< 60 years). Twit Text FOAVip Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34200325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34200325 #FOAvip English Wikipedia <ref>{{Cite pmid|34200325}}</ref> Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors #MMPMID34200325 Mongelli A; Barbi V; Gottardi Zamperla M; Atlante S; Forleo L; Nesta M; Massetti M; Pontecorvi A; Nanni S; Farsetti A; Catalano O; Bussotti M; Dalla Vecchia LA; Bachetti T; Martelli F; La Rovere MT; Gaetano C Int J Mol Sci 2021[Jun]; 22 (11): ä PMID34200325show ga The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called persistent post-COVID-19 syndrome (PPCS) is a common finding. In COVID-19 survivors, PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. In this study, a cohort of 117 COVID-19 survivors (post-COVID-19) and 144 non-infected volunteers (COVID-19-free) was analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. The results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 +/- 7.29 years (+5.25 years above the range of normality) compared with 3.68 +/- 8.17 years for the COVID-19-free population (p < 0.0001). A significant telomere shortening parallels this finding in the post-COVID-19 cohort compared with COVID-19-free subjects (p < 0.0001). Additionally, ACE2 expression was decreased in post-COVID-19 patients, compared with the COVID-19-free population, while DPP-4 did not change. In light of these observations, we hypothesize that some epigenetic alterations are associated with the post-COVID-19 condition, particularly in younger patients (< 60 years). |*CpG Islands[MESH] |*Telomere Shortening[MESH] |Adult[MESH] |Aged[MESH] |Aging/*genetics[MESH] |Angiotensin-Converting Enzyme 2/blood[MESH] |Biomarkers[MESH] |COVID-19/complications/etiology/*genetics/*physiopathology[MESH] |DNA Methylation[MESH] |Dipeptidyl Peptidase 4/blood[MESH] |Epigenomics[MESH] |Female[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Post-Acute COVID-19 Syndrome[MESH] |Risk Factors[MESH] |Survivors[MESH]Evidence for Biological Age Acceleration and Telomere Shortening in CO(epmc).pdf DeepDyve Pubget Overpricing