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10.3390/molecules26113354 http://scihub22266oqcxt.onion/10.3390/molecules26113354 34199488!8199578!34199488     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2021 ; 26 (11): ä Nephropedia Template TP {{tp|p=34199488|t=2021. Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M(pro)) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus |pdf=|usr=}}{{34199488}} gab.com Text Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M(pro)) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=34199488 #FOAvip In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing. Although several other mutants were previously reported, VUI-202012/01 proved to be about 70% more transmissible. Hence, the usefulness and effectiveness of the newly U.S. Food and Drug Administration (FDA)-approved COVID-19 vaccines against these new variants are doubtfully questioned. As a result of these unexpected mutants from COVID-19 and due to lack of time, much research interest is directed toward assessing secondary metabolites as potential candidates for developing lead pharmaceuticals. In this study, a marine-derived fungus Aspergillus terreus was investigated, affording two butenolide derivatives, butyrolactones I (1) and III (2), a meroterpenoid, terretonin (3), and 4-hydroxy-3-(3-methylbut-2-enyl)benzaldehyde (4). Chemical structures were unambiguously determined based on mass spectrometry and extensive 1D/2D NMR analyses experiments. Compounds (1-4) were assessed for their in vitro anti-inflammatory, antiallergic, and in silico COVID-19 main protease (M(pro)) and elastase inhibitory activities. Among the tested compounds, only 1 revealed significant activities comparable to or even more potent than respective standard drugs, which makes butyrolactone I (1) a potential lead entity for developing a new remedy to treat and/or control the currently devastating and deadly effects of COVID-19 pandemic and elastase-related inflammatory complications. Twit Text FOAVip Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M(pro)) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=34199488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34199488 #FOAvip English Wikipedia <ref>{{Cite pmid|34199488}}</ref> Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M(pro)) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus #MMPMID34199488 Uras IS; Ebada SS; Korinek M; Albohy A; Abdulrazik BS; Wang YH; Chen BH; Horng JT; Lin W; Hwang TL; Konuklugil B Molecules 2021[Jun]; 26 (11): ä PMID34199488show ga In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing. Although several other mutants were previously reported, VUI-202012/01 proved to be about 70% more transmissible. Hence, the usefulness and effectiveness of the newly U.S. Food and Drug Administration (FDA)-approved COVID-19 vaccines against these new variants are doubtfully questioned. As a result of these unexpected mutants from COVID-19 and due to lack of time, much research interest is directed toward assessing secondary metabolites as potential candidates for developing lead pharmaceuticals. In this study, a marine-derived fungus Aspergillus terreus was investigated, affording two butenolide derivatives, butyrolactones I (1) and III (2), a meroterpenoid, terretonin (3), and 4-hydroxy-3-(3-methylbut-2-enyl)benzaldehyde (4). Chemical structures were unambiguously determined based on mass spectrometry and extensive 1D/2D NMR analyses experiments. Compounds (1-4) were assessed for their in vitro anti-inflammatory, antiallergic, and in silico COVID-19 main protease (M(pro)) and elastase inhibitory activities. Among the tested compounds, only 1 revealed significant activities comparable to or even more potent than respective standard drugs, which makes butyrolactone I (1) a potential lead entity for developing a new remedy to treat and/or control the currently devastating and deadly effects of COVID-19 pandemic and elastase-related inflammatory complications. |4-Butyrolactone/*analogs & derivatives/chemistry/isolation & purification/metabolism[MESH] |Anti-Allergic Agents/*chemistry/metabolism[MESH] |Anti-Inflammatory Agents/*chemistry/metabolism[MESH] |Aspergillus/*chemistry/growth & development/metabolism[MESH] |Binding Sites[MESH] |COVID-19/pathology/virology[MESH] |Catalytic Domain[MESH] |Humans[MESH] |Leukocyte Elastase/antagonists & inhibitors/metabolism[MESH] |Magnetic Resonance Spectroscopy[MESH] |Molecular Conformation[MESH] |Molecular Docking Simulation[MESH] |Neutrophils/enzymology[MESH] |SARS-CoV-2/*enzymology/isolation & purification[MESH] |Seawater/microbiology[MESH]Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M(pro)) I(epmc).pdf DeepDyve Pubget Overpricing