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10.1042/BCJ20210198 http://scihub22266oqcxt.onion/10.1042/BCJ20210198 34198326!8286829!34198326     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34198326&cmd=llinks): Failed to open stream: HTTP request failed! 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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease |pdf=|usr=}}{{34198326}} gab.com Text Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=34198326 #FOAvip SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is an urgent need for effective antiviral treatments. The only currently approved antiviral treatment for COVID-19 is remdesivir, an inhibitor of viral genome replication. SARS-CoV-2 proliferation relies on the enzymatic activities of the non-structural proteins (nsp), which makes them interesting targets for the development of new antiviral treatments. With the aim to identify novel SARS-CoV-2 antivirals, we have purified the exoribonuclease/methyltransferase (nsp14) and its cofactor (nsp10) and developed biochemical assays compatible with high-throughput approaches to screen for exoribonuclease inhibitors. We have screened a library of over 5000 commercial compounds and identified patulin and aurintricarboxylic acid (ATA) as inhibitors of nsp14 exoribonuclease in vitro. We found that patulin and ATA inhibit replication of SARS-CoV-2 in a VERO E6 cell-culture model. These two new antiviral compounds will be valuable tools for further coronavirus research as well as potentially contributing to new therapeutic opportunities for COVID-19. Twit Text FOAVip Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=34198326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34198326 #FOAvip English Wikipedia <ref>{{Cite pmid|34198326}}</ref> Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease #MMPMID34198326 Canal B; McClure AW; Curran JF; Wu M; Ulferts R; Weissmann F; Zeng J; Bertolin AP; Milligan JC; Basu S; Drury LS; Deegan TD; Fujisawa R; Roberts EL; Basier C; Labib K; Beale R; Howell M; Diffley JFX Biochem J 2021[Jul]; 478 (13): 2445-2464 PMID34198326show ga SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is an urgent need for effective antiviral treatments. The only currently approved antiviral treatment for COVID-19 is remdesivir, an inhibitor of viral genome replication. SARS-CoV-2 proliferation relies on the enzymatic activities of the non-structural proteins (nsp), which makes them interesting targets for the development of new antiviral treatments. With the aim to identify novel SARS-CoV-2 antivirals, we have purified the exoribonuclease/methyltransferase (nsp14) and its cofactor (nsp10) and developed biochemical assays compatible with high-throughput approaches to screen for exoribonuclease inhibitors. We have screened a library of over 5000 commercial compounds and identified patulin and aurintricarboxylic acid (ATA) as inhibitors of nsp14 exoribonuclease in vitro. We found that patulin and ATA inhibit replication of SARS-CoV-2 in a VERO E6 cell-culture model. These two new antiviral compounds will be valuable tools for further coronavirus research as well as potentially contributing to new therapeutic opportunities for COVID-19. |*Drug Evaluation, Preclinical[MESH] |Animals[MESH] |Antiviral Agents/*chemistry/*pharmacology[MESH] |Aurintricarboxylic Acid/pharmacology[MESH] |Chlorocebus aethiops[MESH] |Enzyme Assays[MESH] |Exoribonucleases/*antagonists & inhibitors/metabolism[MESH] |Fluorescence[MESH] |High-Throughput Screening Assays[MESH] |Patulin/pharmacology[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/drug effects/*enzymology[MESH] |Small Molecule Libraries/chemistry/*pharmacology[MESH] |Vero Cells[MESH] |Viral Nonstructural Proteins/*antagonists & inhibitors/metabolism[MESH]Identifying SARS-CoV-2 antiviral compounds by screening for small mole(epmc).pdf DeepDyve Pubget Overpricing