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10.1042/BCJ20210426

http://scihub22266oqcxt.onion/10.1042/BCJ20210426
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34198320!8286811!34198320
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suck abstract from ncbi


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pmid34198320      Biochem+J 2021 ; 478 (13): 2533-2535
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  • Author s overview: identifying SARS-CoV-2 antiviral compounds #MMPMID34198320
  • Diffley JFX
  • Biochem J 2021[Jul]; 478 (13): 2533-2535 PMID34198320show ga
  • In response to the COVID-19 pandemic, we began a project in March 2020 to identify small molecule inhibitors of SARS-CoV-2 enzymes from a library of chemical compounds containing many established pharmaceuticals. Our hope was that inhibitors we found might slow the replication of the SARS-CoV-2 virus in cells and ultimately be useful in the treatment of COVID-19. The seven accompanying manuscripts describe the results of these chemical screens. This overview summarises the main highlights from these screens and discusses the implications of our results and how our results might be exploited in future.
  • |*Drug Evaluation, Preclinical[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*chemistry/*pharmacology[MESH]
  • |Enzyme Assays[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/drug effects/*enzymology[MESH]
  • |Small Molecule Libraries/chemistry/*pharmacology[MESH]


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