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10.1159/000517066

http://scihub22266oqcxt.onion/10.1159/000517066
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34198303!8339025!34198303
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suck abstract from ncbi


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pmid34198303      Neuroepidemiology 2021 ; 55 (5): 381-386
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  • Characteristics Associated with Olfactory and Taste Disorders in COVID-19 #MMPMID34198303
  • Galmiche S; Bruel T; Madec Y; Tondeur L; Grzelak L; Staropoli I; Cailleau I; Ungeheuer MN; Renaudat C; Fernandes Pellerin S; Hoen B; Schwartz O; Fontanet A
  • Neuroepidemiology 2021[]; 55 (5): 381-386 PMID34198303show ga
  • INTRODUCTION: Olfactory and taste disorders (OTDs) have been reported in COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the mechanisms of which remain unclear. We conducted a detailed analysis of OTDs as part of 2 seroepidemiological investigations of COVID-19 outbreaks. METHODS: Two retrospective cohort studies were conducted in a high school and primary schools of Northern France following a COVID-19 epidemic in February-March 2020. Students, their relatives, and school staff were included. Anti-SARS-CoV-2 antibodies were identified using a flow-cytometry-based assay detecting anti-S IgG. RESULTS: Among 2,004 participants (median [IQR] age: 31 [11-43] years), 303 (15.2%) tested positive for SARS-CoV-2 antibodies. OTDs were present in 91 (30.0%) and 92 (30.3%) of them, respectively, and had 85.1 and 78.0% positive predictive values for SARS-CoV-2 infection, respectively. In seropositive participants, OTDs were independently associated with an age above 18 years, female gender, fatigue, and headache. CONCLUSION: This study confirms the higher frequency of OTDs in females than males and adults than children. Their high predictive value for the diagnosis of COVID-19 suggests that they should be systematically searched for in patients with respiratory symptoms, fever, or headache. The association of OTDs with headache, not previously reported, suggests that they share a common mechanism, which deserves further investigation.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/analysis[MESH]
  • |COVID-19/*complications[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Olfaction Disorders/*etiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Taste Disorders/*etiology[MESH]


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