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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Evol+Biol 2021 ; 34 (12): 1867-1877 Nephropedia Template TP
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SARS-CoV-2 virulence evolution: Avirulence theory, immunity and trade-offs #MMPMID34196431
Alizon S; Sofonea MT
J Evol Biol 2021[Dec]; 34 (12): 1867-1877 PMID34196431show ga
The COVID-19 pandemic has led to a resurgence of the debate on whether host-parasite interactions should evolve towards avirulence. In this review, we first show that SARS-CoV-2 virulence is evolving, before explaining why some expect the mortality caused by the epidemic to converge towards that of human seasonal alphacoronaviruses. Leaning on existing theory, we then include viral evolution into the picture and discuss hypotheses explaining why the virulence has increased since the beginning of the pandemic. Finally, we mention some potential scenarios for the future.