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10.1007/s11845-021-02690-4

http://scihub22266oqcxt.onion/10.1007/s11845-021-02690-4
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34195921!8245120!34195921
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suck abstract from ncbi


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pmid34195921      Ir+J+Med+Sci 2022 ; 191 (3): 1023-1028
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  • High anti-SARS-CoV-2 antibody seroprevalence in healthcare workers in an Irish university teaching hospital #MMPMID34195921
  • Leonard A; Prior AR; Reilly P; Murray C; Brien MO; Maguire G; Ennis D; Reid A; Rakovac A; Boran G
  • Ir J Med Sci 2022[Jun]; 191 (3): 1023-1028 PMID34195921show ga
  • INTRODUCTION: Healthcare workers are at very high risk for SARS-CoV-2 exposure and infection. This study evaluated anti-SARS-CoV-2 seroprevalence in healthcare workers in a tertiary care hospital and then correlated seroprevalence with confirmed or suspected SARS-CoV-2 infection in this population since the onset of the COVID-19 pandemic. METHOD: The study was approved by our institution's Joint Research Ethics Committee in June 2020. All volunteers were provided with a consent form, an information leaflet and a questionnaire on the day before phlebotomy. Serum samples were collected from 1176 participants over a 3-month period and analysed using the Elecsys Anti-SARS-CoV-2 assay (Roche Diagnostics GmbH, Mannheim, Germany) which detects total antibodies against the nucleocapsid protein of SARs-COV-2. RESULTS: Overall anti-SARS-CoV-2 seroprevalence among participating healthcare workers was 17.9%. The rate of confirmed infection by real-time polymerase chain reaction molecular testing prior to participation was 12.2%. Of 211 participants who had a reactive antibody test result, 37% did not have COVID-19 infection confirmed at any point prior to participation in this study, either having had a swab which did not detect SARS-CoV-2 RNA or having never been tested. Seropositivity was the highest (30%) in the youngest quintile of age (20-29 years old). Staff with more patient contact had a higher seroprevalence of 19.5% compared to 13.4% in staff with less patient contact. CONCLUSION: This study demonstrates that a substantial proportion of SARS-CoV-2 infections in healthcare workers may be asymptomatic or subclinical and thus potentially represent a significant transmission risk to colleagues and patients.
  • |*COVID-19/epidemiology[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral[MESH]
  • |Health Personnel[MESH]
  • |Hospitals, Teaching[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |RNA, Viral[MESH]
  • |Seroepidemiologic Studies[MESH]
  • |Universities[MESH]


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