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10.3389/fimmu.2021.663303 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.663303 34194429!8236949!34194429     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34194429&cmd=llinks): Failed to open stream: HTTP request failed! 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Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis |pdf=|usr=}}{{34194429}} gab.com Text Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34194429 #FOAvip The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 patients, but their role in disease development is still unknown. The aim of this study is to assess the capacity of NETs to drive epithelial-mesenchymal transition (EMT) of lung epithelial cells and to analyze the involvement of NETs in COVID-19. Bronchoalveolar lavage fluid of severe COVID-19 patients showed high concentration of NETs that correlates with neutrophils count; moreover, the analysis of lung tissues of COVID-19 deceased patients showed a subset of alveolar reactive pneumocytes with a co-expression of epithelial marker and a mesenchymal marker, confirming the induction of EMT mechanism after severe SARS-CoV2 infection. By airway in vitro models, cultivating A549 or 16HBE at air-liquid interface, adding alveolar macrophages (AM), neutrophils and SARS-CoV2, we demonstrated that to trigger a complete EMT expression pattern are necessary the induction of NETosis by SARS-CoV2 and the secretion of AM factors (TGF-beta, IL8 and IL1beta). All our results highlight the possible mechanism that can induce lung fibrosis after SARS-CoV2 infection. Twit Text FOAVip Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34194429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34194429 #FOAvip English Wikipedia <ref>{{Cite pmid|34194429}}</ref> Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis #MMPMID34194429 Pandolfi L; Bozzini S; Frangipane V; Percivalle E; De Luigi A; Violatto MB; Lopez G; Gabanti E; Carsana L; D'Amato M; Morosini M; De Amici M; Nebuloni M; Fossali T; Colombo R; Saracino L; Codullo V; Gnecchi M; Bigini P; Baldanti F; Lilleri D; Meloni F Front Immunol 2021[]; 12 (ä): 663303 PMID34194429show ga The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 patients, but their role in disease development is still unknown. The aim of this study is to assess the capacity of NETs to drive epithelial-mesenchymal transition (EMT) of lung epithelial cells and to analyze the involvement of NETs in COVID-19. Bronchoalveolar lavage fluid of severe COVID-19 patients showed high concentration of NETs that correlates with neutrophils count; moreover, the analysis of lung tissues of COVID-19 deceased patients showed a subset of alveolar reactive pneumocytes with a co-expression of epithelial marker and a mesenchymal marker, confirming the induction of EMT mechanism after severe SARS-CoV2 infection. By airway in vitro models, cultivating A549 or 16HBE at air-liquid interface, adding alveolar macrophages (AM), neutrophils and SARS-CoV2, we demonstrated that to trigger a complete EMT expression pattern are necessary the induction of NETosis by SARS-CoV2 and the secretion of AM factors (TGF-beta, IL8 and IL1beta). All our results highlight the possible mechanism that can induce lung fibrosis after SARS-CoV2 infection. |*Epithelial-Mesenchymal Transition[MESH] |Adult[MESH] |Biopsy[MESH] |Bronchoalveolar Lavage Fluid/cytology[MESH] |COVID-19/complications/immunology/*physiopathology[MESH] |Cell Line[MESH] |Epithelial Cells/pathology[MESH] |Extracellular Traps/*metabolism[MESH] |Humans[MESH] |Lung/pathology[MESH] |Neutrophils/*metabolism[MESH]Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Trans(epmc).pdf DeepDyve Pubget Overpricing