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10.1038/s41598-021-93046-6

http://scihub22266oqcxt.onion/10.1038/s41598-021-93046-6
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suck abstract from ncbi


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pmid34193945      Sci+Rep 2021 ; 11 (1): 13580
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  • Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections-Upper Silesia pilot study #MMPMID34193945
  • Mika J; Tobiasz J; Zyla J; Papiez A; Bach M; Werner A; Kozielski M; Kania M; Gruca A; Piotrowski D; Sobala-Szczygiel B; Wlostowska B; Foszner P; Sikora M; Polanska J; Jaroszewicz J
  • Sci Rep 2021[Jun]; 11 (1): 13580 PMID34193945show ga
  • In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33, p < 0.0001), body temperature above 38? (OR = 1.67, p < 0.0001), muscle aches (OR = 1.30, p = 0.0242), headache (OR = 1.27, p = 0.0405), cough (OR = 1.26, p = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55, p < 0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28, p < 0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72, p = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 (p < 0.0001). Temperature > 38? with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.
  • |*SARS-CoV-2[MESH]
  • |Academic Medical Centers/statistics & numerical data[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Ageusia/etiology[MESH]
  • |COVID-19/complications/*diagnosis/*epidemiology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cough/etiology[MESH]
  • |Diagnosis, Differential[MESH]
  • |Dyspnea/etiology[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Headache/etiology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Odds Ratio[MESH]
  • |Olfaction Disorders/etiology[MESH]
  • |Pilot Projects[MESH]
  • |Poland/epidemiology[MESH]
  • |Respiratory Tract Infections/complications/*diagnosis/*epidemiology/microbiology[MESH]
  • |Surveys and Questionnaires[MESH]
  • |Symptom Assessment/classification/*statistics & numerical data[MESH]


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