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10.1159/000515278 http://scihub22266oqcxt.onion/10.1159/000515278 34192120!8089424!34192120     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Dis+(Basel) 2021 ; 5 (5): 1-10 Nephropedia Template TP {{tp|p=34192120|t=2021. Hydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with Nonmalaria Diseases |pdf=|usr=}}{{34192120}} gab.com Text Hydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with Nonmalaria Diseases JO: Kidney Dis (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34192120 #FOAvip BACKGROUND: The COVID-19 pandemic has brought increased focus on hydroxychloroquine (HCQ), as doctors, the medical community, and policymakers around the world attempt to understand how the risks of HCQ weigh against unknown benefits. We aim to evaluate the effects of HCQ on cardiac conduction, thus contributing to the global understanding of implications of HCQ use. METHODS: We reviewed 717 cases of nonmalaria patients treated with HCQ (302) or without HCQ (415) in our hospital from 2008 to 2019, analyzed the cardiac conduction recorded by electrocardiogram (122 vs. 180) including heart rate (HR), PR, and corrected-QT (QTc) intervals, and explored the relationship of cardiac conduction with age, HCQ dosage, HCQ duration, sex, and primary diseases in HCQ users. RESULTS: The all-cause mortality is similar between HCQ and non-HCQ groups (4.0 vs. 4.3%, p = 0.85). Patients aged 45 years or older, not younger ones, have lower HR (80.1 +/- 1.7 vs. 85.7 +/- 1.8 bpm, p = 0.03) but longer PR (163 +/- 3.4 vs. 146.6 +/- 4.2 ms, p = 0.003) and QTc (417.8 +/- 3.8 vs. 407.7 +/- 2.7 ms, p = 0.03) in HCQ than those in non-HCQ. The age in the HCQ group is positively correlated with PR (R = 0.31, p < 0.01) and QTc (R = 0.34, p < 0.01) but not HR. HR, PR, and QTc are not related to HCQ dosage (0.1-0.6 g/day), HCQ duration (0.2-126 months), sex, primary diseases, and repeated exams. CONCLUSION: Age is the most important risk factor of HCQ on cardiac conduction in nonmalaria patients. Electrocardiogram monitoring is suggested in aged patients due to the effects of HCQ on HR, PR, and QTc. Twit Text FOAVip Hydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with Nonmalaria Diseases ????Kidney Dis (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34192120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34192120 #FOAvip English Wikipedia <ref>{{Cite pmid|34192120}}</ref> Hydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with Nonmalaria Diseases #MMPMID34192120 Yu Y; Xu J; Xie A; Liu S; Wang X; Zhu R; Wang X Kidney Dis (Basel) 2021[Apr]; 5 (5): 1-10 PMID34192120show ga BACKGROUND: The COVID-19 pandemic has brought increased focus on hydroxychloroquine (HCQ), as doctors, the medical community, and policymakers around the world attempt to understand how the risks of HCQ weigh against unknown benefits. We aim to evaluate the effects of HCQ on cardiac conduction, thus contributing to the global understanding of implications of HCQ use. METHODS: We reviewed 717 cases of nonmalaria patients treated with HCQ (302) or without HCQ (415) in our hospital from 2008 to 2019, analyzed the cardiac conduction recorded by electrocardiogram (122 vs. 180) including heart rate (HR), PR, and corrected-QT (QTc) intervals, and explored the relationship of cardiac conduction with age, HCQ dosage, HCQ duration, sex, and primary diseases in HCQ users. RESULTS: The all-cause mortality is similar between HCQ and non-HCQ groups (4.0 vs. 4.3%, p = 0.85). Patients aged 45 years or older, not younger ones, have lower HR (80.1 +/- 1.7 vs. 85.7 +/- 1.8 bpm, p = 0.03) but longer PR (163 +/- 3.4 vs. 146.6 +/- 4.2 ms, p = 0.003) and QTc (417.8 +/- 3.8 vs. 407.7 +/- 2.7 ms, p = 0.03) in HCQ than those in non-HCQ. The age in the HCQ group is positively correlated with PR (R = 0.31, p < 0.01) and QTc (R = 0.34, p < 0.01) but not HR. HR, PR, and QTc are not related to HCQ dosage (0.1-0.6 g/day), HCQ duration (0.2-126 months), sex, primary diseases, and repeated exams. CONCLUSION: Age is the most important risk factor of HCQ on cardiac conduction in nonmalaria patients. Electrocardiogram monitoring is suggested in aged patients due to the effects of HCQ on HR, PR, and QTc. äHydroxychloroquine Inhibits Cardiac Conduction in Aged Patients with N(epmc).pdf DeepDyve Pubget Overpricing