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10.1590/1516-3180.2020.0722.R1.2302021 http://scihub22266oqcxt.onion/10.1590/1516-3180.2020.0722.R1.2302021 34190873!9615598!34190873     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34190873&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sao+Paulo+Med+J 2021 ; 139 (4): 398-404 Nephropedia Template TP {{tp|p=34190873|t=2021. Could serum total cortisol level at admission predict mortality due to coronavirus disease 2019 in the intensive care unit? A prospective study |pdf=|usr=}}{{34190873}} gab.com Text Could serum total cortisol level at admission predict mortality due to coronavirus disease 2019 in the intensive care unit A prospective study JO: Sao Paulo Med J http://www.kidney.de/pget.php?&tw=1&pmid=34190873 #FOAvip BACKGROUND: Critical diseases usually cause hypercortisolemia via activation of the hypothalamic-pituitary-adrenal axis. OBJECTIVES: To investigate the relationship between serum total cortisol level and mortality among coronavirus disease 2019 (COVID-19) patients in the intensive care unit (ICU), at the time of their admission. DESIGN AND SETTING: Prospective study developed in a pandemic hospital in the city of Sirnak, Turkey. METHODS: We compared the serum total cortisol levels of 285 patients (141 COVID-19-negative patients and 144 COVID-19-positive patients) followed up in the ICU. RESULTS: The median cortisol level of COVID-19-positive patients was higher than that of COVID-19 negative patients (21.84 mug/dl versus 16.47 mug/dl; P < 0.001). In multivariate logistic regression analysis, mortality was associated with higher cortisol level (odds ratio: 1.20; 95% confidence interval: 1.08-1.35; P = 0.001). The cortisol cutoff point was 31 mug/dl (855 nmol/l) for predicting mortality among COVID-19-positive patients (area under the curve 0.932; sensitivity 59%; and specificity 95%). Among the COVID-19 positive patients with cortisol level </= 31 mug/dl (79%; 114 patients), the median survival was higher than among those with cortisol level > 31 mug/dl (21%; 30 patients) (32 days versus 19 days; log-rank test P < 0.001). CONCLUSION: Very high cortisol levels are associated with severe illness and increased risk of death, among COVID-19 patients in the ICU. Twit Text FOAVip Could serum total cortisol level at admission predict mortality due to coronavirus disease 2019 in the intensive care unit A prospective study ????Sao Paulo Med J http://www.kidney.de/pget.php?&tw=1&pmid=34190873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34190873 #FOAvip English Wikipedia <ref>{{Cite pmid|34190873}}</ref> Could serum total cortisol level at admission predict mortality due to coronavirus disease 2019 in the intensive care unit? A prospective study #MMPMID34190873 Guven M; Gultekin H Sao Paulo Med J 2021[Jul]; 139 (4): 398-404 PMID34190873show ga BACKGROUND: Critical diseases usually cause hypercortisolemia via activation of the hypothalamic-pituitary-adrenal axis. OBJECTIVES: To investigate the relationship between serum total cortisol level and mortality among coronavirus disease 2019 (COVID-19) patients in the intensive care unit (ICU), at the time of their admission. DESIGN AND SETTING: Prospective study developed in a pandemic hospital in the city of Sirnak, Turkey. METHODS: We compared the serum total cortisol levels of 285 patients (141 COVID-19-negative patients and 144 COVID-19-positive patients) followed up in the ICU. RESULTS: The median cortisol level of COVID-19-positive patients was higher than that of COVID-19 negative patients (21.84 mug/dl versus 16.47 mug/dl; P < 0.001). In multivariate logistic regression analysis, mortality was associated with higher cortisol level (odds ratio: 1.20; 95% confidence interval: 1.08-1.35; P = 0.001). The cortisol cutoff point was 31 mug/dl (855 nmol/l) for predicting mortality among COVID-19-positive patients (area under the curve 0.932; sensitivity 59%; and specificity 95%). Among the COVID-19 positive patients with cortisol level 31 mug/dl (21%; 30 patients) (32 days versus 19 days; log-rank test P < 0.001). CONCLUSION: Very high cortisol levels are associated with severe illness and increased risk of death, among COVID-19 patients in the ICU. |*COVID-19[MESH] |*Hydrocortisone[MESH] |Humans[MESH] |Hypothalamo-Hypophyseal System[MESH] |Intensive Care Units[MESH] |Pituitary-Adrenal System[MESH] |Prospective Studies[MESH]Could serum total cortisol level at admission predict mortality due to(epmc).pdf DeepDyve Pubget Overpricing