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10.1039/d1cc02267a

http://scihub22266oqcxt.onion/10.1039/d1cc02267a
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34190246!ä!34190246

suck abstract from ncbi


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pmid34190246      Chem+Commun+(Camb) 2021 ; 57 (57): 6979-6982
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  • Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering #MMPMID34190246
  • Mesias VSD; Zhu H; Tang X; Dai X; Guo Y; Liu W; Huang J
  • Chem Commun (Camb) 2021[Jul]; 57 (57): 6979-6982 PMID34190246show ga
  • The infection of coronavirus initiates with the binding between its spike protein receptor binding domain (RBD) and a human cellular receptor called angiotensin-converting enzyme 2 (ACE2). Here, we construct truncated ACE2 peptide-conjugated gold nanoparticles as antiviral scaffolds and study their binding with the SARS-CoV-2 RBD using dynamic light scattering (DLS). Systematic DLS analysis identifies the effective peptide-nanoparticle conjugation and its efficient, specific, and long-lasting multivalent binding towards the RBD with a binding affinity of 41 nM, indicating the potential of this antiviral platform to compete with natural ACE2-RBD interactions for viral blocking and showcasing an accessible approach to measure the binding constants and kinetics.
  • |*SARS-CoV-2[MESH]
  • |Angiotensin-Converting Enzyme 2/*chemistry[MESH]
  • |Dynamic Light Scattering[MESH]
  • |Molecular Dynamics Simulation[MESH]
  • |Nanoparticles/*chemistry[MESH]
  • |Peptide Fragments/*chemistry/*metabolism[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]


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