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10.1002/jev2.12112 http://scihub22266oqcxt.onion/10.1002/jev2.12112 34188786!8213968!34188786     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Extracell+Vesicles 2021 ; 10 (8): e12112 Nephropedia Template TP {{tp|p=34188786|t=2021. Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies |pdf=|usr=}}{{34188786}} gab.com Text Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies JO: J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=34188786 #FOAvip In late 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. SARS-CoV-2 and the disease it causes, coronavirus disease 2019 (COVID-19), spread rapidly and became a global pandemic in early 2020. SARS-CoV-2 spike protein is responsible for viral entry and binds to angiotensin converting enzyme 2 (ACE2) on host cells, making it a major target of the immune system - particularly neutralizing antibodies (nAbs) that are induced by infection or vaccines. Extracellular vesicles (EVs) are small membraned particles constitutively released by cells, including virally-infected cells. EVs and viruses enclosed within lipid membranes share some characteristics: they are small, sub-micron particles and they overlap in cellular biogenesis and egress routes. Given their shared characteristics, we hypothesized that EVs released from spike-expressing cells could carry spike and serve as decoys for anti-spike nAbs, promoting viral infection. Here, using mass spectrometry and nanoscale flow cytometry (NFC) approaches, we demonstrate that SARS-CoV-2 spike protein can be incorporated into EVs. Furthermore, we show that spike-carrying EVs act as decoy targets for convalescent patient serum-derived nAbs, reducing their effectiveness in blocking viral entry. These findings have important implications for the pathogenesis of SARS-CoV-2 infection in vivo and highlight the complex interplay between viruses, extracellular vesicles, and the immune system that occurs during viral infections. Twit Text FOAVip Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies ????J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=34188786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34188786 #FOAvip English Wikipedia <ref>{{Cite pmid|34188786}}</ref> Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies #MMPMID34188786 Troyer Z; Alhusaini N; Tabler CO; Sweet T; de Carvalho KIL; Schlatzer DM; Carias L; King CL; Matreyek K; Tilton JC J Extracell Vesicles 2021[Jun]; 10 (8): e12112 PMID34188786show ga In late 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. SARS-CoV-2 and the disease it causes, coronavirus disease 2019 (COVID-19), spread rapidly and became a global pandemic in early 2020. SARS-CoV-2 spike protein is responsible for viral entry and binds to angiotensin converting enzyme 2 (ACE2) on host cells, making it a major target of the immune system - particularly neutralizing antibodies (nAbs) that are induced by infection or vaccines. Extracellular vesicles (EVs) are small membraned particles constitutively released by cells, including virally-infected cells. EVs and viruses enclosed within lipid membranes share some characteristics: they are small, sub-micron particles and they overlap in cellular biogenesis and egress routes. Given their shared characteristics, we hypothesized that EVs released from spike-expressing cells could carry spike and serve as decoys for anti-spike nAbs, promoting viral infection. Here, using mass spectrometry and nanoscale flow cytometry (NFC) approaches, we demonstrate that SARS-CoV-2 spike protein can be incorporated into EVs. Furthermore, we show that spike-carrying EVs act as decoy targets for convalescent patient serum-derived nAbs, reducing their effectiveness in blocking viral entry. These findings have important implications for the pathogenesis of SARS-CoV-2 infection in vivo and highlight the complex interplay between viruses, extracellular vesicles, and the immune system that occurs during viral infections. |Antibodies, Neutralizing/*immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/immunology/*therapy/virology[MESH] |Extracellular Vesicles/*chemistry[MESH] |Flow Cytometry[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Protein Binding[MESH] |SARS-CoV-2/*physiology[MESH]Extracellular vesicles carry SARS-CoV-2 spike protein and serve as dec(epmc).pdf DeepDyve Pubget Overpricing