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10.1038/s41598-021-92941-2 http://scihub22266oqcxt.onion/10.1038/s41598-021-92941-2 34188167!8242070!34188167     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 13464 Nephropedia Template TP {{tp|p=34188167|t=2021. Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2 |pdf=|usr=}}{{34188167}} gab.com Text Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34188167 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and such an unbalanced production of proinflammatory cytokines is linked to acute respiratory distress syndrome with high mortality in COVID-19 patients. Our study provides evidence that the ORF3a, M, ORF7a, and N proteins of SARS-CoV-2 were NF-kappaB activators. The viral sequence from infected zoo lions belonged to clade V, and a single mutation of G251V is found for ORF3a gene compared to all other clades. No significant functional difference was found for clade V ORF3a, indicating the NF-kappaB activation is conserved among COVID-19 variants. Of the four viral proteins, the ORF7a protein induced the NF-kappaB dictated proinflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-8, IL-10, TNF-alpha, and IFNbeta. The ORF7a protein also induced IL-3, IL-4, IL-7, IL-23. Of 15 different chemokines examined in the study, CCL11, CCL17, CCL19, CCL20, CCL21, CCL22, CCL25, CCL26, CCL27, and CXCL9 were significantly upregulated by ORF7. These cytokines and chemokines were frequently elevated in severely ill COVID-19 patients. Our data provide an insight into how SARS-CoV-2 modulates NF-kappaB signaling and inflammatory cytokine expressions. The ORF7a protein may be a desirable target for strategic developments to minimize uncontrolled inflammation in COVID-19 patients. Twit Text FOAVip Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34188167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34188167 #FOAvip English Wikipedia <ref>{{Cite pmid|34188167}}</ref> Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2 #MMPMID34188167 Su CM; Wang L; Yoo D Sci Rep 2021[Jun]; 11 (1): 13464 PMID34188167show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and such an unbalanced production of proinflammatory cytokines is linked to acute respiratory distress syndrome with high mortality in COVID-19 patients. Our study provides evidence that the ORF3a, M, ORF7a, and N proteins of SARS-CoV-2 were NF-kappaB activators. The viral sequence from infected zoo lions belonged to clade V, and a single mutation of G251V is found for ORF3a gene compared to all other clades. No significant functional difference was found for clade V ORF3a, indicating the NF-kappaB activation is conserved among COVID-19 variants. Of the four viral proteins, the ORF7a protein induced the NF-kappaB dictated proinflammatory cytokines including IL-1alpha, IL-1beta, IL-6, IL-8, IL-10, TNF-alpha, and IFNbeta. The ORF7a protein also induced IL-3, IL-4, IL-7, IL-23. Of 15 different chemokines examined in the study, CCL11, CCL17, CCL19, CCL20, CCL21, CCL22, CCL25, CCL26, CCL27, and CXCL9 were significantly upregulated by ORF7. These cytokines and chemokines were frequently elevated in severely ill COVID-19 patients. Our data provide an insight into how SARS-CoV-2 modulates NF-kappaB signaling and inflammatory cytokine expressions. The ORF7a protein may be a desirable target for strategic developments to minimize uncontrolled inflammation in COVID-19 patients. |Amino Acid Sequence[MESH] |COVID-19/pathology/virology[MESH] |Chemokines/genetics/metabolism[MESH] |Cytokines/genetics/*metabolism[MESH] |HeLa Cells[MESH] |Humans[MESH] |NF-kappa B/*metabolism[MESH] |Point Mutation[MESH] |SARS-CoV-2/isolation & purification/*metabolism[MESH] |Sequence Alignment[MESH] |Severity of Illness Index[MESH] |Up-Regulation[MESH] |Viral Matrix Proteins/genetics[MESH] |Viral Proteins/genetics/*metabolism[MESH]Activation of NF-kappaB and induction of proinflammatory cytokine expr(epmc).pdf DeepDyve Pubget Overpricing