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10.1038/s41598-021-92979-2 http://scihub22266oqcxt.onion/10.1038/s41598-021-92979-2 34188154!8241995!34188154     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 13533 Nephropedia Template TP {{tp|p=34188154|t=2021. Increased colonic expression of ACE2 associates with poor prognosis in Crohn s disease |pdf=|usr=}}{{34188154}} gab.com Text Increased colonic expression of ACE2 associates with poor prognosis in Crohn s disease JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34188154 #FOAvip The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease (non-IBD) controls. We hypothesized that the colonic expression levels of ACE2 impacts CD course. We examined the expression of colonic ACE2 in 67 adult CD and 14 NIBD control patients using RNA-seq and quantitative (q) RT-PCR. We validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry. The impact of increased ACE2 expression in CD for the risk of surgery was evaluated by a multivariate regression analysis and a Kaplan-Meier estimator. To provide critical support for the generality of our findings, we analyzed previously published RNA-seq data from two large independent cohorts of CD patients. Colonic ACE2 expression was significantly higher in a subset of adult CD patients which was defined as the ACE2-high CD subset. IHC in a sampling of ACE2-high CD patients confirmed high ACE2 protein expression in the colon and ileum compared to ACE2-low CD and NIBD patients. Notably, we found that ACE2-high CD patients are significantly more likely to undergo surgery within 5 years of CD diagnosis, and a Cox regression analysis found that high ACE2 levels is an independent risk factor for surgery (OR 2.17; 95% CI, 1.10-4.26; p = 0.025). Increased intestinal expression of ACE2 is associated with deteriorated clinical outcomes in CD patients. These data point to the need for molecular stratification that can impact CD disease-related outcomes. Twit Text FOAVip Increased colonic expression of ACE2 associates with poor prognosis in Crohn s disease ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34188154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34188154 #FOAvip English Wikipedia <ref>{{Cite pmid|34188154}}</ref> Increased colonic expression of ACE2 associates with poor prognosis in Crohn s disease #MMPMID34188154 Toyonaga T; Araba KC; Kennedy MM; Keith BP; Wolber EA; Beasley C; Steinbach EC; Schaner MR; Jain A; Long MD; Barnes EL; Herfarth HH; Isaacs KL; Hansen JJ; Kapadia MR; Guillem JG; Gulati AS; Sethupathy P; Furey TS; Ehre C; Sheikh SZ Sci Rep 2021[Jun]; 11 (1): 13533 PMID34188154show ga The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's disease (CD) and non-inflammatory bowel disease (non-IBD) controls. We hypothesized that the colonic expression levels of ACE2 impacts CD course. We examined the expression of colonic ACE2 in 67 adult CD and 14 NIBD control patients using RNA-seq and quantitative (q) RT-PCR. We validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry. The impact of increased ACE2 expression in CD for the risk of surgery was evaluated by a multivariate regression analysis and a Kaplan-Meier estimator. To provide critical support for the generality of our findings, we analyzed previously published RNA-seq data from two large independent cohorts of CD patients. Colonic ACE2 expression was significantly higher in a subset of adult CD patients which was defined as the ACE2-high CD subset. IHC in a sampling of ACE2-high CD patients confirmed high ACE2 protein expression in the colon and ileum compared to ACE2-low CD and NIBD patients. Notably, we found that ACE2-high CD patients are significantly more likely to undergo surgery within 5 years of CD diagnosis, and a Cox regression analysis found that high ACE2 levels is an independent risk factor for surgery (OR 2.17; 95% CI, 1.10-4.26; p = 0.025). Increased intestinal expression of ACE2 is associated with deteriorated clinical outcomes in CD patients. These data point to the need for molecular stratification that can impact CD disease-related outcomes. |Adolescent[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Crohn Disease/metabolism/*pathology/surgery[MESH] |Female[MESH] |Humans[MESH] |Ileum/metabolism/pathology[MESH] |Immunohistochemistry[MESH] |Inflammatory Bowel Diseases/metabolism/pathology[MESH] |Male[MESH] |Prognosis[MESH] |Proportional Hazards Models[MESH] |RNA, Messenger/chemistry/metabolism[MESH] |Risk Factors[MESH] |Sequence Analysis, RNA[MESH]Increased colonic expression of ACE2 associates with poor prognosis in(epmc).pdf DeepDyve Pubget Overpricing