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10.1016/j.tibs.2021.06.001

http://scihub22266oqcxt.onion/10.1016/j.tibs.2021.06.001
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34187722!8180548!34187722
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suck abstract from ncbi

pmid34187722      Trends+Biochem+Sci 2021 ; 46 (10): 848-860
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  • Cell entry by SARS-CoV-2 #MMPMID34187722
  • Peng R; Wu LA; Wang Q; Qi J; Gao GF
  • Trends Biochem Sci 2021[Oct]; 46 (10): 848-860 PMID34187722show ga
  • Severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that further mediates fusion between viral and cellular membranes. The host membrane protein, angiotensin-converting enzyme 2 (ACE2), is the major receptor for SARS-CoV-2 and is a crucial determinant for cross-species transmission. In addition, some auxiliary receptors and cofactors are also involved that expand the host/tissue tropism of SARS-CoV-2. After receptor engagement, specific proteases are required that cleave the S protein and trigger its fusogenic activity. Here we discuss the recent advances in understanding the molecular events during SARS-CoV-2 entry which will contribute to developing vaccines and therapeutics.
  • |*COVID-19[MESH]
  • |*Spike Glycoprotein, Coronavirus/metabolism[MESH]
  • |Humans[MESH]
  • |Protein Binding[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2[MESH]


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