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10.1111/febs.16096

http://scihub22266oqcxt.onion/10.1111/febs.16096
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34185437!8420456!34185437
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suck abstract from ncbi


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pmid34185437      FEBS+J 2021 ; 288 (17): 5122-5129
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  • Targeting neuropilins as a viable SARS-CoV-2 treatment #MMPMID34185437
  • Sarabipour S; Mac Gabhann F
  • FEBS J 2021[Sep]; 288 (17): 5122-5129 PMID34185437show ga
  • The SARS-CoV-2 pandemic has significantly impacted global health. Research on viral mechanisms, highly effective vaccines, and other therapies is in progress. Neuropilins have recently been identified as host cell receptors enabling viral fusion. Here, we provide context to neuropilin's tissue-specific role in infection and the potential impact of NRP-based therapeutics. We conclude that the central roles of neuropilins in vascular, neural, and other pathways may render it a less suitable target for treating SARS-CoV-2 than agents that target its binding partner, the viral spike protein.
  • |Antibodies, Neutralizing/immunology/*therapeutic use[MESH]
  • |Antibodies, Viral/immunology/*therapeutic use[MESH]
  • |COVID-19/blood/*therapy/virology[MESH]
  • |Humans[MESH]
  • |Neuropilins/*genetics/immunology[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]


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