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10.1038/s41587-021-00950-3 http://scihub22266oqcxt.onion/10.1038/s41587-021-00950-3 34183860!ä!34183860 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2021 ; 39 (11): 1366-1374 Nephropedia Template TP {{tp|p=34183860|t=2021. Wearable materials with embedded synthetic biology sensors for biomolecule detection |pdf=|usr=}}{{34183860}} gab.com Text Wearable materials with embedded synthetic biology sensors for biomolecule detection JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34183860 #FOAvip Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits generally requires the presence of living, engineered bacteria, which has limited their application in wearables. Here we report lightweight, flexible substrates and textiles functionalized with freeze-dried, cell-free synthetic circuits, including CRISPR-based tools, that detect metabolites, chemicals and pathogen nucleic acid signatures. The wearable devices are activated upon rehydration from aqueous exposure events and report the presence of specific molecular targets by colorimetric changes or via an optical fiber network that detects fluorescent and luminescent outputs. The detection limits for nucleic acids rival current laboratory methods such as quantitative PCR. We demonstrate the development of a face mask with a lyophilized CRISPR sensor for wearable, noninvasive detection of SARS-CoV-2 at room temperature within 90 min, requiring no user intervention other than the press of a button. Twit Text FOAVip Wearable materials with embedded synthetic biology sensors for biomolecule detection ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34183860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34183860 #FOAvip English Wikipedia <ref>{{Cite pmid|34183860}}</ref> Wearable materials with embedded synthetic biology sensors for biomolecule detection #MMPMID34183860 Nguyen PQ; Soenksen LR; Donghia NM; Angenent-Mari NM; de Puig H; Huang A; Lee R; Slomovic S; Galbersanini T; Lansberry G; Sallum HM; Zhao EM; Niemi JB; Collins JJ Nat Biotechnol 2021[Nov]; 39 (11): 1366-1374 PMID34183860show ga Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits generally requires the presence of living, engineered bacteria, which has limited their application in wearables. Here we report lightweight, flexible substrates and textiles functionalized with freeze-dried, cell-free synthetic circuits, including CRISPR-based tools, that detect metabolites, chemicals and pathogen nucleic acid signatures. The wearable devices are activated upon rehydration from aqueous exposure events and report the presence of specific molecular targets by colorimetric changes or via an optical fiber network that detects fluorescent and luminescent outputs. The detection limits for nucleic acids rival current laboratory methods such as quantitative PCR. We demonstrate the development of a face mask with a lyophilized CRISPR sensor for wearable, noninvasive detection of SARS-CoV-2 at room temperature within 90 min, requiring no user intervention other than the press of a button. |*COVID-19/diagnosis[MESH] |*Synthetic Biology[MESH] |*Wearable Electronic Devices[MESH] |Biosensing Techniques/*instrumentation[MESH] |Humans[MESH] |SARS-CoV-2/*isolation & purification[MESH]Wearable materials with embedded synthetic biology sensors for biomole(epmc).pdf DeepDyve Pubget Overpricing