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10.1016/j.cytogfr.2021.06.002 http://scihub22266oqcxt.onion/10.1016/j.cytogfr.2021.06.002 34183243!8233448!34183243     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine+Growth+Factor+Rev 2021 ; 61 (ä): 2-15 Nephropedia Template TP {{tp|p=34183243|t=2021. The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies |pdf=|usr=}}{{34183243}} gab.com Text The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies JO: Cytokine Growth Factor Rev http://www.kidney.de/pget.php?&tw=1&pmid=34183243 #FOAvip Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations, ranging from asymptomatic cases to severe pneumonia or even death. In severe COVID-19 cases, an increased level of proinflammatory cytokines has been observed in the bloodstream, forming the so-called "cytokine storm". Generally, nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation intensely induces cytokine production as an inflammatory response to viral infection. Therefore, the NLRP3 inflammasome can be a potential target for the treatment of COVID-19. Hence, this review first introduces the canonical NLRP3 inflammasome activation pathway. Second, we review the cellular/molecular mechanisms of NLRP3 inflammasome activation by SARS-CoV-2 infection (e.g., viroporins, ion flux and the complement cascade). Furthermore, we describe the involvement of the NLRP3 inflammasome in the pathogenesis of COVID-19 (e.g., cytokine storm, respiratory manifestations, cardiovascular comorbidity and neurological symptoms). Finally, we also propose several promising inhibitors targeting the NLRP3 inflammasome, cytokine products and neutrophils to provide novel therapeutic strategies for COVID-19. Twit Text FOAVip The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies ????Cytokine Growth Factor Rev http://www.kidney.de/pget.php?&tw=1&pmid=34183243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34183243 #FOAvip English Wikipedia <ref>{{Cite pmid|34183243}}</ref> The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies #MMPMID34183243 Zhao N; Di B; Xu LL Cytokine Growth Factor Rev 2021[Oct]; 61 (ä): 2-15 PMID34183243show ga Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations, ranging from asymptomatic cases to severe pneumonia or even death. In severe COVID-19 cases, an increased level of proinflammatory cytokines has been observed in the bloodstream, forming the so-called "cytokine storm". Generally, nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation intensely induces cytokine production as an inflammatory response to viral infection. Therefore, the NLRP3 inflammasome can be a potential target for the treatment of COVID-19. Hence, this review first introduces the canonical NLRP3 inflammasome activation pathway. Second, we review the cellular/molecular mechanisms of NLRP3 inflammasome activation by SARS-CoV-2 infection (e.g., viroporins, ion flux and the complement cascade). Furthermore, we describe the involvement of the NLRP3 inflammasome in the pathogenesis of COVID-19 (e.g., cytokine storm, respiratory manifestations, cardiovascular comorbidity and neurological symptoms). Finally, we also propose several promising inhibitors targeting the NLRP3 inflammasome, cytokine products and neutrophils to provide novel therapeutic strategies for COVID-19. |*COVID-19 Drug Treatment[MESH] |COVID-19/*metabolism[MESH] |Cytokine Release Syndrome/drug therapy/metabolism[MESH] |Humans[MESH] |Inflammasomes/drug effects/*metabolism[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism[MESH]The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and ther(epmc).pdf DeepDyve Pubget Overpricing