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10.1016/j.addr.2021.113848 http://scihub22266oqcxt.onion/10.1016/j.addr.2021.113848 34182016!8233062!34182016     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2021 ; 178 (ä): 113848 Nephropedia Template TP {{tp|p=34182016|t=2021. Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19 |pdf=|usr=}}{{34182016}} gab.com Text Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19 JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=34182016 #FOAvip The emergence of SARS-CoV-2, and the ensuing global pandemic, has resulted in an unprecedented response to identify therapies that can limit uncontrolled inflammation observed in patients with moderate to severe COVID-19. The immune pathology behind COVID-19 is complex and involves the activation and interaction of multiple systems including, but not limited to, complement, inflammasomes, endothelial as well as innate and adaptive immune cells to bring about a convoluted profile of inflammation, coagulation and tissue damage. To date, therapeutic approaches have focussed on inhibition of coagulation, untargeted immune suppression and/or cytokine-directed blocking agents. Regardless of recently achieved improvements in individual patient outcomes and survival rates, improved and focussed approaches targeting individual systems involved is needed to further improve prognosis and wellbeing. This review summarizes the current understanding of molecular and cellular systems involved in the pathophysiology of COVID-19, and their contribution to pathogen clearance and damage to then discuss possible therapeutic options involving immunomodulatory drug delivery systems as well as summarising the complex interplay between them. Twit Text FOAVip Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19 ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=34182016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34182016 #FOAvip English Wikipedia <ref>{{Cite pmid|34182016}}</ref> Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19 #MMPMID34182016 Brain D; Plant-Hately A; Heaton B; Arshad U; David C; Hedrich C; Owen A; Liptrott NJ Adv Drug Deliv Rev 2021[Nov]; 178 (ä): 113848 PMID34182016show ga The emergence of SARS-CoV-2, and the ensuing global pandemic, has resulted in an unprecedented response to identify therapies that can limit uncontrolled inflammation observed in patients with moderate to severe COVID-19. The immune pathology behind COVID-19 is complex and involves the activation and interaction of multiple systems including, but not limited to, complement, inflammasomes, endothelial as well as innate and adaptive immune cells to bring about a convoluted profile of inflammation, coagulation and tissue damage. To date, therapeutic approaches have focussed on inhibition of coagulation, untargeted immune suppression and/or cytokine-directed blocking agents. Regardless of recently achieved improvements in individual patient outcomes and survival rates, improved and focussed approaches targeting individual systems involved is needed to further improve prognosis and wellbeing. This review summarizes the current understanding of molecular and cellular systems involved in the pathophysiology of COVID-19, and their contribution to pathogen clearance and damage to then discuss possible therapeutic options involving immunomodulatory drug delivery systems as well as summarising the complex interplay between them. |*COVID-19 Drug Treatment[MESH] |Adjuvants, Immunologic/administration & dosage[MESH] |Animals[MESH] |Antiviral Agents/*administration & dosage/immunology[MESH] |COVID-19/immunology[MESH] |Communicable Diseases/drug therapy/immunology[MESH] |Complement Activation/drug effects/immunology[MESH] |Drug Delivery Systems/*methods/trends[MESH] |Humans[MESH] |Immunologic Factors/*administration & dosage/immunology[MESH]Drug delivery systems as immunomodulators for therapy of infectious di(epmc).pdf DeepDyve Pubget Overpricing