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suck abstract from ncbi


10.1016/j.cbi.2021.109568

http://scihub22266oqcxt.onion/10.1016/j.cbi.2021.109568
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34181887!ä!34181887

suck abstract from ncbi


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pmid34181887      Chem+Biol+Interact 2021 ; 345 (ä): 109568
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  • Nuclear factor-kappa B and its role in inflammatory lung disease #MMPMID34181887
  • Alharbi KS; Fuloria NK; Fuloria S; Rahman SB; Al-Malki WH; Javed Shaikh MA; Thangavelu L; Singh SK; Rama Raju Allam VS; Jha NK; Chellappan DK; Dua K; Gupta G
  • Chem Biol Interact 2021[Aug]; 345 (ä): 109568 PMID34181887show ga
  • Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-kappaB signaling, which is a member of the Rel protein family. Five members of this family c-REL, NF-kappaB2 (p100/p52), RelA (p65), NF-kappaB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-kappaB activation. NF-kappaB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-kappaB a key target for drug production.
  • |Animals[MESH]
  • |Humans[MESH]
  • |Inflammation/complications[MESH]
  • |Lung Diseases/complications/drug therapy/immunology/*metabolism[MESH]


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