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10.36255/exonpublications.prostatecancer.combinationtreatment.2021

http://scihub22266oqcxt.onion/10.36255/exonpublications.prostatecancer.combinationtreatment.2021
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34181378!ä!34181378

suck abstract from ncbi


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pmid34181378      Prostate+Cancer-/-ä 2021 ; ä (ä): ä
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  • Combination Treatment Options for Castration-Resistant Prostate Cancer #MMPMID34181378
  • Miller DR; Ingersoll MA; Teply BA; Lin MF
  • Prostate Cancer-/-ä 2021[May]; ä (ä): ä PMID34181378show ga
  • Prostate cancer is the most commonly diagnosed solid tumor and the second leading cause of cancer-related deaths in men in the United States. While localized prostate cancer has an excellent prognosis for patients, about one-third of patients are diagnosed with high-risk disease, including metastatic cancer. The 5-year survival rate of metastatic prostate cancer is only about 30%. Due to the androgen dependence of prostate cancer cells, androgen-deprivation therapy is the standard of care for metastatic prostate cancer, which includes both surgical and medical approaches. Nevertheless, androgen-deprivation therapy in general is not curative; patients can develop castration-resistant prostate cancer. Despite current chemotherapies, including the utilization of novel androgen signaling inhibitors and immunotherapy, patients still succumb to the disease. Hence, castration-resistant prostate cancer is a lethal disease. Combination treatment is a strategy for treating this lethal disease and thus will be the focus of discussion in this chapter.
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