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10.1021/acs.jproteome.1c00206

http://scihub22266oqcxt.onion/10.1021/acs.jproteome.1c00206
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34180678!ä!34180678

suck abstract from ncbi

pmid34180678      J+Proteome+Res 2021 ; 20 (8): 4212-4215
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  • Genetic Variability of the SARS-CoV-2 Pocketome #MMPMID34180678
  • Yazdani S; De Maio N; Ding Y; Shahani V; Goldman N; Schapira M
  • J Proteome Res 2021[Aug]; 20 (8): 4212-4215 PMID34180678show ga
  • In the absence of effective treatment, COVID-19 is likely to remain a global disease burden. Compounding this threat is the near certainty that novel coronaviruses with pandemic potential will emerge in years to come. Pan-coronavirus drugs-agents active against both SARS-CoV-2 and other coronaviruses-would address both threats. A strategy to develop such broad-spectrum inhibitors is to pharmacologically target binding sites on SARS-CoV-2 proteins that are highly conserved in other known coronaviruses, the assumption being that any selective pressure to keep a site conserved across past viruses will apply to future ones. Here we systematically mapped druggable binding pockets on the experimental structure of 15 SARS-CoV-2 proteins and analyzed their variation across 27 alpha- and beta-coronaviruses and across thousands of SARS-CoV-2 samples from COVID-19 patients. We find that the two most conserved druggable sites are a pocket overlapping the RNA binding site of the helicase nsp13 and the catalytic site of the RNA-dependent RNA polymerase nsp12, both components of the viral replication-transcription complex. We present the data on a public web portal (https://www.thesgc.org/SARSCoV2_pocketome/), where users can interactively navigate individual protein structures and view the genetic variability of drug-binding pockets in 3D.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antiviral Agents/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]


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