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10.1016/j.isci.2021.102738 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102738 34179732!8216762!34179732     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34179732&cmd=llinks): Failed to open stream: HTTP request failed! 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Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution |pdf=|usr=}}{{34179732}} gab.com Text Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34179732 #FOAvip Severe COVID-19 is accompanied by rampant immune dysregulation in the lung and periphery, with immune cells of both compartments contributing to systemic distress. The extent to which immune cells of the lung and blood enter similar or distinct pathological states during severe disease remains unknown. Here, we leveraged 96 publicly available single-cell RNA sequencing datasets to elucidate common and compartment-specific features of severe to critical COVID-19 at the levels of transcript expression, biological pathways, and ligand-receptor signaling networks. Comparing severe patients to milder and healthy donors, we identified distinct differential gene expression signatures between compartments and a core set of co-directionally regulated surface markers. A majority of severity-enriched pathways were shared, whereas TNF and interferon responses were polarized. Severity-specific ligand-receptor networks appeared to be differentially active in both compartments. Overall, our results describe a nuanced response during severe COVID-19 where compartment plays a role in dictating the pathological state of immune cells. Twit Text FOAVip Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34179732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34179732 #FOAvip English Wikipedia <ref>{{Cite pmid|34179732}}</ref> Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution #MMPMID34179732 Overholt KJ; Krog JR; Zanoni I; Bryson BD iScience 2021[Jul]; 24 (7): 102738 PMID34179732show ga Severe COVID-19 is accompanied by rampant immune dysregulation in the lung and periphery, with immune cells of both compartments contributing to systemic distress. The extent to which immune cells of the lung and blood enter similar or distinct pathological states during severe disease remains unknown. Here, we leveraged 96 publicly available single-cell RNA sequencing datasets to elucidate common and compartment-specific features of severe to critical COVID-19 at the levels of transcript expression, biological pathways, and ligand-receptor signaling networks. Comparing severe patients to milder and healthy donors, we identified distinct differential gene expression signatures between compartments and a core set of co-directionally regulated surface markers. A majority of severity-enriched pathways were shared, whereas TNF and interferon responses were polarized. Severity-specific ligand-receptor networks appeared to be differentially active in both compartments. Overall, our results describe a nuanced response during severe COVID-19 where compartment plays a role in dictating the pathological state of immune cells. äDissecting the common and compartment-specific features of COVID-19 se(epmc).pdf DeepDyve Pubget Overpricing