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10.3389/fimmu.2021.686240 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.686240 34177935!8219958!34177935     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 686240 Nephropedia Template TP {{tp|p=34177935|t=2021. Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients |pdf=|usr=}}{{34177935}} gab.com Text Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34177935 #FOAvip A disruption of the crosstalk between the gut and the lung has been implicated as a driver of severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts gut barrier integrity, increasing the permeability to gut microbes and their products. This exacerbates inflammation, resulting in positive feedback. We aimed to test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers of disrupted gut permeability. We applied a multi-omic systems biology approach to analyze plasma samples from COVID-19 patients with varying disease severity and SARS-CoV-2 negative controls. We investigated the potential links between plasma markers of gut barrier integrity, microbial translocation, systemic inflammation, metabolome, lipidome, and glycome, and COVID-19 severity. We found that severe COVID-19 is associated with high levels of markers of tight junction permeability and translocation of bacterial and fungal products into the blood. These markers of disrupted intestinal barrier integrity and microbial translocation correlate strongly with higher levels of markers of systemic inflammation and immune activation, lower levels of markers of intestinal function, disrupted plasma metabolome and glycome, and higher mortality rate. Our study highlights an underappreciated factor with significant clinical implications, disruption in gut functions, as a potential force that may contribute to COVID-19 severity. Twit Text FOAVip Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34177935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34177935 #FOAvip English Wikipedia <ref>{{Cite pmid|34177935}}</ref> Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients #MMPMID34177935 Giron LB; Dweep H; Yin X; Wang H; Damra M; Goldman AR; Gorman N; Palmer CS; Tang HY; Shaikh MW; Forsyth CB; Balk RA; Zilberstein NF; Liu Q; Kossenkov A; Keshavarzian A; Landay A; Abdel-Mohsen M Front Immunol 2021[]; 12 (ä): 686240 PMID34177935show ga A disruption of the crosstalk between the gut and the lung has been implicated as a driver of severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts gut barrier integrity, increasing the permeability to gut microbes and their products. This exacerbates inflammation, resulting in positive feedback. We aimed to test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers of disrupted gut permeability. We applied a multi-omic systems biology approach to analyze plasma samples from COVID-19 patients with varying disease severity and SARS-CoV-2 negative controls. We investigated the potential links between plasma markers of gut barrier integrity, microbial translocation, systemic inflammation, metabolome, lipidome, and glycome, and COVID-19 severity. We found that severe COVID-19 is associated with high levels of markers of tight junction permeability and translocation of bacterial and fungal products into the blood. These markers of disrupted intestinal barrier integrity and microbial translocation correlate strongly with higher levels of markers of systemic inflammation and immune activation, lower levels of markers of intestinal function, disrupted plasma metabolome and glycome, and higher mortality rate. Our study highlights an underappreciated factor with significant clinical implications, disruption in gut functions, as a potential force that may contribute to COVID-19 severity. |COVID-19/*immunology[MESH] |Female[MESH] |Gastrointestinal Microbiome/*immunology[MESH] |Glycomics[MESH] |Haptoglobins/metabolism[MESH] |Humans[MESH] |Inflammation/*immunology[MESH] |Intestines/*physiology[MESH] |Lipidomics[MESH] |Male[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Permeability[MESH] |Protein Precursors/metabolism[MESH] |SARS-CoV-2/*physiology[MESH]Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patien(epmc).pdf DeepDyve Pubget Overpricing