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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Indian+J+Clin+Biochem 2021 ; 36 (4): 485-491 Nephropedia Template TP
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Combined Analysis of Anti SARS-CoV-2 IgG and IgM Responses in COVID19 Patients in India #MMPMID34177138
Chidananda MK; Zohmangaihi D; Ram S; Soni SL; Suri V; Malhotra P; Jassal RS; Kaur J; Verma I; Sharma S
Indian J Clin Biochem 2021[Oct]; 36 (4): 485-491 PMID34177138show ga
Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global health problem, India being the second most affected country. The kinetics of antibody response to SARS-CoV-2 in Indian population is not studied yet. To understand serological response in relation to age, gender, time period and severity of disease, Roche Elecsys anti-SARS-CoV-2 test was used which analysed both IgM and IgG. One hundred and three COVID-19 patients were enrolled. Seropositivity was seen in 64% of patients, with 33% at = 7 days, 62% between 8 and 15 days and 81% at >/= 16 days from the time of admission. Men (65%) showed higher antibody response than women (59%), whereas no difference was observed in seropositivity with respect to age of the patients. Dynamics of antibody responses revealed individual variations. Patients in ICU had higher antibody reactivity with 67% positivity as compared to 60% positivity in non-ICU patients. Kinetics of antibody response during COVID-19 disease varied in relation to gender, age, time period and severity and these factors might play an important role in treatment and control of COVID-19.