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10.12932/AP-130121-1037 http://scihub22266oqcxt.onion/10.12932/AP-130121-1037 34174806!ä!34174806 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Asian+Pac+J+Allergy+Immunol 2021 ; 39 (2): 69-77 Nephropedia Template TP {{tp|p=34174806|t=2021. Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets |pdf=|usr=}}{{34174806}} gab.com Text Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets JO: Asian Pac J Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34174806 #FOAvip A novel severe acute respiratory syndrome COVID-19 caused by coronavirus SARS-CoV-2 has been confirmed to infect more than 100 million people globally, with mortality reaching nearly 3 million as of March 2021. The symptoms vary widely, from the absence of any symptoms to death. The severity of COVID-19 relates to hyperinflammatory conditions with acute respiratory distress syndrome (ARDS), which leads to multiple-organ failure and death. Innate immunity plays an important role in the early response to SARS-CoV-2 infection and regulates the pathogenesis and its clinical outcomes. The most severe cases of COVID-19 present with increased innate immune cell infiltration in the lung, and elevated pro-inflammatory cytokines in the blood serum that are associated with disease severity. Here we review the innate immune response to SARS-CoV-2 infection based on the recent reports and discuss the potential roles of innate immune cells and their mediators in pathogenesis that dictate the outcome of the disease. Understanding the roles of innate immune responses at the initial stages of infection may provide early windows into treatment and clues for vaccine development. Twit Text FOAVip Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets ????Asian Pac J Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34174806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34174806 #FOAvip English Wikipedia <ref>{{Cite pmid|34174806}}</ref> Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets #MMPMID34174806 Ruenjaiman V; Hirankarn N; Palaga T Asian Pac J Allergy Immunol 2021[Jun]; 39 (2): 69-77 PMID34174806show ga A novel severe acute respiratory syndrome COVID-19 caused by coronavirus SARS-CoV-2 has been confirmed to infect more than 100 million people globally, with mortality reaching nearly 3 million as of March 2021. The symptoms vary widely, from the absence of any symptoms to death. The severity of COVID-19 relates to hyperinflammatory conditions with acute respiratory distress syndrome (ARDS), which leads to multiple-organ failure and death. Innate immunity plays an important role in the early response to SARS-CoV-2 infection and regulates the pathogenesis and its clinical outcomes. The most severe cases of COVID-19 present with increased innate immune cell infiltration in the lung, and elevated pro-inflammatory cytokines in the blood serum that are associated with disease severity. Here we review the innate immune response to SARS-CoV-2 infection based on the recent reports and discuss the potential roles of innate immune cells and their mediators in pathogenesis that dictate the outcome of the disease. Understanding the roles of innate immune responses at the initial stages of infection may provide early windows into treatment and clues for vaccine development. |*Immunity, Innate/drug effects[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |Biomarkers/blood[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Vaccines/therapeutic use[MESH] |COVID-19/diagnosis/*immunology/virology[MESH] |Cytokines/blood[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |SARS-CoV-2/drug effects/*immunology/pathogenicity[MESH]Innate immunity in COVID-19: Drivers of pathogenesis and potential the(epmc).pdf DeepDyve Pubget Overpricing