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10.1016/j.cmi.2021.06.013 http://scihub22266oqcxt.onion/10.1016/j.cmi.2021.06.013 34174397!8223011!34174397     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Microbiol+Infect 2021 ; 27 (11): 1672-1677 Nephropedia Template TP {{tp|p=34174397|t=2021. B- and T-cell immune responses elicited by the Comirnaty(R) COVID-19 vaccine in nursing-home residents |pdf=|usr=}}{{34174397}} gab.com Text B- and T-cell immune responses elicited by the Comirnaty(R) COVID-19 vaccine in nursing-home residents JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=34174397 #FOAvip OBJECTIVES: The immunogenicity of the Comirnaty(R) vaccine against coronavirus disease 2019 (COVID-19) has not been adequately studied in elderly people with comorbidities. We assessed antibody and T-cell responses targeted to the S protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following full vaccination in nursing-home residents. METHODS: Sixty nursing-home residents (44 female, age 53-100 years), of whom ten had previously been diagnosed with COVID-19, and 18 healthy controls (15 female, age 27-54 years) were recruited. Pre- and post-vaccination blood specimens were available for quantification of total antibodies binding the SARS-CoV-2 S protein and for enumeration of SARS-CoV-2 S-reactive IFN-gamma CD4(+) and CD8(+) T cells by flow cytometry. RESULTS: The seroconversion rate in (presumably) SARS-CoV-2-naive nursing-home residents (41/43, 95.3%) was similar to that in controls (17/18, 94.4%). A booster effect was documented in post-vaccination samples of nursing-home residents with prior COVID-19. Plasma antibody levels were higher (p < 0.01) in recovered nursing-home residents (all 2500 IU/mL) than in individuals across the other two groups (median 1120 IU/mL in naive nursing-home residents and 2211 IU/ml in controls). A large percentage of nursing-home residents had SARS-CoV-2 S-reactive IFN-gamma CD8(+) (naive 31/49, 63.2%; recovered 8/10, 80%) or CD4(+) T cells (naive 35/49, 71.4%; recovered 7/10, 70%) at baseline, in contrast to healthy controls (3/17, 17.6% and 5/17, 29%, respectively). SARS-CoV-2 IFN-gamma CD8(+) and CD4(+) T-cell responses were documented in 88% (15/17) and all control subjects after vaccination, respectively, but only in 65.5% (38/58) and 22.4% (13/58) of nursing-home residents. Overall, the median frequency of SARS-CoV-2 IFN-gamma CD8(+) and CD4(+) T cells in nursing-home residents decreased in post-vaccination specimens, whereas it increased in controls. CONCLUSION: The Comirnaty COVID-19 vaccine elicits robust SARS-CoV-2 S antibody responses in nursing-home residents. Nevertheless, the rate and frequency of detectable SARS-CoV-2 IFN-gamma T-cell responses after vaccination was lower in nursing-home residents than in controls. Twit Text FOAVip B- and T-cell immune responses elicited by the Comirnaty(R) COVID-19 vaccine in nursing-home residents ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=34174397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34174397 #FOAvip English Wikipedia <ref>{{Cite pmid|34174397}}</ref> B- and T-cell immune responses elicited by the Comirnaty(R) COVID-19 vaccine in nursing-home residents #MMPMID34174397 Torres I; Albert E; Gimenez E; Alcaraz MJ; Botija P; Amat P; Remigia MJ; Beltran MJ; Rodado C; Huntley D; Olea B; Navarro D Clin Microbiol Infect 2021[Nov]; 27 (11): 1672-1677 PMID34174397show ga OBJECTIVES: The immunogenicity of the Comirnaty(R) vaccine against coronavirus disease 2019 (COVID-19) has not been adequately studied in elderly people with comorbidities. We assessed antibody and T-cell responses targeted to the S protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following full vaccination in nursing-home residents. METHODS: Sixty nursing-home residents (44 female, age 53-100 years), of whom ten had previously been diagnosed with COVID-19, and 18 healthy controls (15 female, age 27-54 years) were recruited. Pre- and post-vaccination blood specimens were available for quantification of total antibodies binding the SARS-CoV-2 S protein and for enumeration of SARS-CoV-2 S-reactive IFN-gamma CD4(+) and CD8(+) T cells by flow cytometry. RESULTS: The seroconversion rate in (presumably) SARS-CoV-2-naive nursing-home residents (41/43, 95.3%) was similar to that in controls (17/18, 94.4%). A booster effect was documented in post-vaccination samples of nursing-home residents with prior COVID-19. Plasma antibody levels were higher (p < 0.01) in recovered nursing-home residents (all 2500 IU/mL) than in individuals across the other two groups (median 1120 IU/mL in naive nursing-home residents and 2211 IU/ml in controls). A large percentage of nursing-home residents had SARS-CoV-2 S-reactive IFN-gamma CD8(+) (naive 31/49, 63.2%; recovered 8/10, 80%) or CD4(+) T cells (naive 35/49, 71.4%; recovered 7/10, 70%) at baseline, in contrast to healthy controls (3/17, 17.6% and 5/17, 29%, respectively). SARS-CoV-2 IFN-gamma CD8(+) and CD4(+) T-cell responses were documented in 88% (15/17) and all control subjects after vaccination, respectively, but only in 65.5% (38/58) and 22.4% (13/58) of nursing-home residents. Overall, the median frequency of SARS-CoV-2 IFN-gamma CD8(+) and CD4(+) T cells in nursing-home residents decreased in post-vaccination specimens, whereas it increased in controls. CONCLUSION: The Comirnaty COVID-19 vaccine elicits robust SARS-CoV-2 S antibody responses in nursing-home residents. Nevertheless, the rate and frequency of detectable SARS-CoV-2 IFN-gamma T-cell responses after vaccination was lower in nursing-home residents than in controls. |*COVID-19 Vaccines/immunology[MESH] |*COVID-19/immunology/prevention & control[MESH] |*T-Lymphocytes/immunology[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral[MESH] |B-Lymphocytes/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity[MESH] |Interferon-gamma/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Nursing Homes[MESH]B- and T-cell immune responses elicited by the Comirnaty(R) COVID-19 v(epmc).pdf DeepDyve Pubget Overpricing