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10.1002/advs.202100965 http://scihub22266oqcxt.onion/10.1002/advs.202100965 34174177!8373167!34174177     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2021 ; 8 (16): e2100965 Nephropedia Template TP {{tp|p=34174177|t=2021. Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2 |pdf=|usr=}}{{34174177}} gab.com Text Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2 JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34174177 #FOAvip Rapid progress has been made to identify and study the causative agent leading to coronavirus disease 2019 (COVID-19) but many questions including who is most susceptible and what determines severity remain unanswered. Angiotensin-converting enzyme 2 (ACE2) is a key factor in the infection process of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In this study, molecularly specific positron emission tomography imaging agents for targeting ACE2 are first developed, and these novel agents are evaluated in vitro, in preclinical model systems, and in a first-in-human translational ACE2 imaging of healthy volunteers and a SARS-CoV-2 recovered patient (NCT04422457). ACE2 expression levels in different organs in live subjects are quantitatively delineated and observable differences are measured in the patient recovered from COVID-19. Surprising sites of uptake in the breast, reproductive system and very low uptake in pulmonary tissues are reported. This novel method can add a unique tool to facilitate SARS-CoV-2 related research and improve understanding of this enigmatic disease. Molecular imaging provides quantitative annotation of ACE2, the SARS-CoV-2 entry receptor, to noninvasively monitor organs impacted by the COVID-19. Twit Text FOAVip Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2 ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=34174177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34174177 #FOAvip English Wikipedia <ref>{{Cite pmid|34174177}}</ref> Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2 #MMPMID34174177 Zhu H; Zhang H; Zhou N; Ding J; Jiang J; Liu T; Liu Z; Wang F; Zhang Q; Zhang Z; Yan S; Li L; Benabdallah N; Jin H; Liu Z; Cai L; Thorek DLJ; Yang X; Yang Z Adv Sci (Weinh) 2021[Aug]; 8 (16): e2100965 PMID34174177show ga Rapid progress has been made to identify and study the causative agent leading to coronavirus disease 2019 (COVID-19) but many questions including who is most susceptible and what determines severity remain unanswered. Angiotensin-converting enzyme 2 (ACE2) is a key factor in the infection process of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In this study, molecularly specific positron emission tomography imaging agents for targeting ACE2 are first developed, and these novel agents are evaluated in vitro, in preclinical model systems, and in a first-in-human translational ACE2 imaging of healthy volunteers and a SARS-CoV-2 recovered patient (NCT04422457). ACE2 expression levels in different organs in live subjects are quantitatively delineated and observable differences are measured in the patient recovered from COVID-19. Surprising sites of uptake in the breast, reproductive system and very low uptake in pulmonary tissues are reported. This novel method can add a unique tool to facilitate SARS-CoV-2 related research and improve understanding of this enigmatic disease. Molecular imaging provides quantitative annotation of ACE2, the SARS-CoV-2 entry receptor, to noninvasively monitor organs impacted by the COVID-19. |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |COVID-19/*metabolism/pathology/*virology[MESH] |Cells, Cultured[MESH] |Female[MESH] |Gallium Radioisotopes/pharmacokinetics[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Peptides/*pharmacokinetics[MESH] |Positron Emission Tomography Computed Tomography[MESH] |Protein Binding[MESH] |SARS-CoV-2/isolation & purification/*metabolism/pathogenicity[MESH] |Tissue Distribution[MESH]Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications fo(epmc).pdf DeepDyve Pubget Overpricing