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10.1016/j.medmic.2020.100023

http://scihub22266oqcxt.onion/10.1016/j.medmic.2020.100023
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suck abstract from ncbi


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pmid34173452      Med+Microecol 2020 ; 5 (ä): 100023
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  • Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18 #MMPMID34173452
  • Tao W; Zhang G; Wang X; Guo M; Zeng W; Xu Z; Cao D; Pan A; Wang Y; Zhang K; Ma X; Chen Z; Jin T; Liu L; Weng J; Zhu S
  • Med Microecol 2020[Sep]; 5 (ä): 100023 PMID34173452show ga
  • The ongoing global pandemic of COVID-19 disease, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mainly infect lung epithelial cells, and spread mainly through respiratory droplets. However, recent studies showed potential intestinal infection of SARS-CoV-2, implicated the possibility that the intestinal infection of SARS-CoV-2 may correlate with the dysbiosis of gut microbiota, as well as the severity of COVID-19 symptoms. Here, we investigated the alteration of the gut microbiota in COVID-19 patients, as well as analyzed the correlation between the altered microbes and the levels of intestinal inflammatory cytokine IL-18, which was reported to be elevated in the serum of in COVID-19 patients. Comparing with healthy controls or seasonal flu patients, the gut microbiota showed significantly reduced diversity, with increased opportunistic pathogens in COVID-19 patients. Also, IL-18 level was higher in the fecal samples of COVID-19 patients than in those of either healthy controls or seasonal flu patients. Moreover, the IL-18 levels were even higher in the fecal supernatants obtained from COVID-19 patients that tested positive for SARS-CoV-2 RNA than those that tested negative in fecal samples. These results indicate that changes in gut microbiota composition might contribute to SARS-CoV-2-induced production of inflammatory cytokines in the intestine and potentially also to the onset of a cytokine storm.
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