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10.1038/s41598-021-92547-8 http://scihub22266oqcxt.onion/10.1038/s41598-021-92547-8 34172780!8233413!34172780     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 13300 Nephropedia Template TP {{tp|p=34172780|t=2021. A gain-of-function NLRP3 3 -UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression |pdf=|usr=}}{{34172780}} gab.com Text A gain-of-function NLRP3 3 -UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34172780 #FOAvip Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. In this study, we evaluated the genetic association of NLRP3 polymorphisms with sepsis (640 patients and 769 controls) and characterized the impact of NLRP3 polymorphisms on NLRP3 expression and inflammatory responses. No significant differences were observed in genotype/allelic frequencies of NLRP3 29940G>C between sepsis cases and controls. The G allele was significantly overrepresented in patients with septic shock than those in sepsis subgroup, and the GC/GG genetypes were related to the 28-day mortality of sepsis. Lipopolysaccharide challenge to peripheral blood mononuclear cells showed a significant suppression of NLRP3 mRNA expression and release of IL-1beta and TNF-alpha in CC compared with the GC/GG genotype category. Functional experiments with luciferase reporter vectors containing the NLRP3 3'-UTR with the 29940 G-to-C variation in HUVECs and THP-1 cells showed a potential suppressive effect of miR-146a on NLRP3 transcription in the presence of the C allele. Taken together, these results demonstrated that the 29940 G-to-C mutation within the NLRP3 3'-UTR was a gain-of-function alteration that caused the suppression of NLRP3 expression and downstream inflammatory cytokine production via binding with miR-146a, which ultimately protected patients against susceptibility to sepsis progression and poor clinical outcome. Twit Text FOAVip A gain-of-function NLRP3 3 -UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34172780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34172780 #FOAvip English Wikipedia <ref>{{Cite pmid|34172780}}</ref> A gain-of-function NLRP3 3 -UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression #MMPMID34172780 Lu F; Chen H; Hong Y; Lin Y; Liu L; Wei N; Wu Q; Liao S; Yang S; He J; Shao Y Sci Rep 2021[Jun]; 11 (1): 13300 PMID34172780show ga Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. In this study, we evaluated the genetic association of NLRP3 polymorphisms with sepsis (640 patients and 769 controls) and characterized the impact of NLRP3 polymorphisms on NLRP3 expression and inflammatory responses. No significant differences were observed in genotype/allelic frequencies of NLRP3 29940G>C between sepsis cases and controls. The G allele was significantly overrepresented in patients with septic shock than those in sepsis subgroup, and the GC/GG genetypes were related to the 28-day mortality of sepsis. Lipopolysaccharide challenge to peripheral blood mononuclear cells showed a significant suppression of NLRP3 mRNA expression and release of IL-1beta and TNF-alpha in CC compared with the GC/GG genotype category. Functional experiments with luciferase reporter vectors containing the NLRP3 3'-UTR with the 29940 G-to-C variation in HUVECs and THP-1 cells showed a potential suppressive effect of miR-146a on NLRP3 transcription in the presence of the C allele. Taken together, these results demonstrated that the 29940 G-to-C mutation within the NLRP3 3'-UTR was a gain-of-function alteration that caused the suppression of NLRP3 expression and downstream inflammatory cytokine production via binding with miR-146a, which ultimately protected patients against susceptibility to sepsis progression and poor clinical outcome. |*MicroRNAs/metabolism[MESH] |*Sepsis/epidemiology/genetics[MESH] |China/epidemiology[MESH] |Cytokines/metabolism[MESH] |Disease Progression[MESH] |Disease Susceptibility[MESH] |Female[MESH] |Gain of Function Mutation[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Inflammasomes/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*genetics[MESH] |Polymorphism, Genetic[MESH]A gain-of-function NLRP3 3 -UTR polymorphism causes miR-146a-mediated (epmc).pdf DeepDyve Pubget Overpricing