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10.1016/j.compbiolchem.2021.107532 http://scihub22266oqcxt.onion/10.1016/j.compbiolchem.2021.107532 34171504!8213524!34171504     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Biol+Chem 2021 ; 93 (ä): 107532 Nephropedia Template TP {{tp|p=34171504|t=2021. A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19) |pdf=|usr=}}{{34171504}} gab.com Text A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19) JO: Comput Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=34171504 #FOAvip Zoonotic Novel coronavirus disease 2019 (COVID-19) is highly pathogenic and transmissible considered as emerging pandemic disease. The virus belongs from a large virus Coronaviridae family affect respiratory tract of animal and human likely originated from bat and homology to SARA-CoV and MERS-CoV. The virus consists of single-stranded positive genomic RNA coated by nucleocapsid protein. The rate of mutation in any virulence gene may influence the phenomenon of host radiation. We have studied the molecular evolution of selected virulence genes (HA, N, RdRP and S) of novel COVID-19. We used a site-specific comparison of synonymous (silent) and non-synonymous (amino acid altering) nucleotide substitutions. Maximum Likelihood genealogies based on differential gamma distribution rates were used for the analysis of null and alternate hypothesis. The null hypothesis was found more suitable for the analysis using Likelihood Ratio Test (LRT) method, confirming higher rate of substitution. The analysis revealed that RdRP gene had the fastest rate evolution followed by HA gene. We have also reported the new motifs for different virulence genes, which are further useful to design new detection and diagnosis kit for COVID -19. Twit Text FOAVip A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19) ????Comput Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=34171504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34171504 #FOAvip English Wikipedia <ref>{{Cite pmid|34171504}}</ref> A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19) #MMPMID34171504 Kumari P; Poddar R Comput Biol Chem 2021[Aug]; 93 (ä): 107532 PMID34171504show ga Zoonotic Novel coronavirus disease 2019 (COVID-19) is highly pathogenic and transmissible considered as emerging pandemic disease. The virus belongs from a large virus Coronaviridae family affect respiratory tract of animal and human likely originated from bat and homology to SARA-CoV and MERS-CoV. The virus consists of single-stranded positive genomic RNA coated by nucleocapsid protein. The rate of mutation in any virulence gene may influence the phenomenon of host radiation. We have studied the molecular evolution of selected virulence genes (HA, N, RdRP and S) of novel COVID-19. We used a site-specific comparison of synonymous (silent) and non-synonymous (amino acid altering) nucleotide substitutions. Maximum Likelihood genealogies based on differential gamma distribution rates were used for the analysis of null and alternate hypothesis. The null hypothesis was found more suitable for the analysis using Likelihood Ratio Test (LRT) method, confirming higher rate of substitution. The analysis revealed that RdRP gene had the fastest rate evolution followed by HA gene. We have also reported the new motifs for different virulence genes, which are further useful to design new detection and diagnosis kit for COVID -19. |Amino Acid Substitution[MESH] |Base Sequence[MESH] |Coronavirus Nucleocapsid Proteins/*genetics[MESH] |Coronavirus RNA-Dependent RNA Polymerase/*genetics[MESH] |Evolution, Molecular[MESH] |Genes, Viral[MESH] |Hemagglutinins/*genetics[MESH] |Phosphoproteins/genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH]A computational analysis of molecular evolution for virulence genes of(epmc).pdf DeepDyve Pubget Overpricing