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10.1016/j.chom.2021.06.006 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.06.006 34171266!8205251!34171266     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (7): 1124-1136.e11 Nephropedia Template TP {{tp|p=34171266|t=2021. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity |pdf=|usr=}}{{34171266}} gab.com Text SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34171266 #FOAvip Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral immunity has been investigated, sensitivity to human leukocyte antigen (HLA)-restricted cellular immunity remains largely unexplored. Here, we demonstrate that two recently emerging mutations in the receptor-binding domain of the SARS-CoV-2 spike protein, L452R (in B.1.427/429 and B.1.617) and Y453F (in B.1.1.298), confer escape from HLA-A24-restricted cellular immunity. These mutations reinforce affinity toward the host entry receptor ACE2. Notably, the L452R mutation increases spike stability, viral infectivity, viral fusogenicity, and thereby promotes viral replication. These data suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes and that a further threat of the SARS-CoV-2 pandemic is escape from cellular immunity. Twit Text FOAVip SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34171266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34171266 #FOAvip English Wikipedia <ref>{{Cite pmid|34171266}}</ref> SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity #MMPMID34171266 Motozono C; Toyoda M; Zahradnik J; Saito A; Nasser H; Tan TS; Ngare I; Kimura I; Uriu K; Kosugi Y; Yue Y; Shimizu R; Ito J; Torii S; Yonekawa A; Shimono N; Nagasaki Y; Minami R; Toya T; Sekiya N; Fukuhara T; Matsuura Y; Schreiber G; Ikeda T; Nakagawa S; Ueno T; Sato K Cell Host Microbe 2021[Jul]; 29 (7): 1124-1136.e11 PMID34171266show ga Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These mutations can affect viral properties such as infectivity and immune resistance. Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral immunity has been investigated, sensitivity to human leukocyte antigen (HLA)-restricted cellular immunity remains largely unexplored. Here, we demonstrate that two recently emerging mutations in the receptor-binding domain of the SARS-CoV-2 spike protein, L452R (in B.1.427/429 and B.1.617) and Y453F (in B.1.1.298), confer escape from HLA-A24-restricted cellular immunity. These mutations reinforce affinity toward the host entry receptor ACE2. Notably, the L452R mutation increases spike stability, viral infectivity, viral fusogenicity, and thereby promotes viral replication. These data suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes and that a further threat of the SARS-CoV-2 pandemic is escape from cellular immunity. |*Immunity, Cellular[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19/epidemiology/*virology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Mutation[MESH] |Phylogeny[MESH] |Protein Binding[MESH] |SARS-CoV-2/*genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*genetics/*immunology[MESH] |Viral Proteins/genetics[MESH]SARS-CoV-2 spike L452R variant evades cellular immunity and increases (epmc).pdf DeepDyve Pubget Overpricing