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10.1002/jmv.27152

http://scihub22266oqcxt.onion/10.1002/jmv.27152
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34170519!8426830!34170519
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suck abstract from ncbi


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pmid34170519      J+Med+Virol 2021 ; 93 (12): 6506-6511
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  • Over 1-year duration and age difference of SARS-CoV-2 antibodies in convalescent COVID-19 patients #MMPMID34170519
  • Zeng F; Wu M; Wang J; Li J; Hu G; Wang L
  • J Med Virol 2021[Dec]; 93 (12): 6506-6511 PMID34170519show ga
  • Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglouilin G (IgG) and immunoglouilin M (IgM) antibodies have been widely used to assist clinical diagnosis. Our previous study reported a discrepancy in SARS-CoV-2 antibody response between male and female coronavirus disease 2019 (COVID-19) patients. However, the duration and discrepancy between ages as well as sexes of SARS-CoV-2 antibody in convalescent COVID-19 patients have not been clarified. In this study, a total of 538 health-examination individuals who were confirmed with SARS-CoV-2 infection a year ago were enrolled. Blood samples were collected and detected for IgM and IgG antibodies. Among these convalescent patients, 12.80% were detected positive for IgM antibodies. The positive rates for IgM antibody were close between sexes: for males, this is 9.17% and for females 13.75%. However, the IgG antibody was detected positive in as much as 82.90% convalescent patients and the positive rates were nearly the same between males (82.57%) and females (82.98%). Besides this, the level of IgM and IgG antibodies showed no difference between male and female convalescent patients. The level of IgG antibodies showed a significant difference between ages. The elder patients (over 35 years old) maintained a higher level of IgG antibody than the younger patients (under or equal 35 years old) after recovering for 1 year. In addition, IgG antibody was more vulnerable to disappear in younger patients than in elder patients. Overall, our study identified over 1-year duration of SARS-CoV-2 antibody and age difference of IgG antibody response in convalescent COVID-19 patients. These findings may provide new insights into long-term humoral immune response, vaccines efficacy and age-based personalized vaccination strategies.
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Sex Factors[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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