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Comorbidity status of deceased COVID-19 in-patients in Italy #MMPMID34169447
Vetrano DL; Tazzeo C; Palmieri L; Marengoni A; Zucchelli A; Lo Noce C; Onder G
Aging Clin Exp Res 2021[Aug]; 33 (8): 2361-2365 PMID34169447show ga
BACKGROUND: Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated. METHODS: A random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values >/= 1.5. RESULTS: Six pairs of diseases exhibited O/E values >/= 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity. CONCLUSION: In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.
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Aging+Clin+Exp+Res 2021 ; 33 (8): 2361-2365
