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10.3748/wjg.v27.i22.2944

http://scihub22266oqcxt.onion/10.3748/wjg.v27.i22.2944
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34168400!8192291!34168400
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suck abstract from ncbi


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pmid34168400      World+J+Gastroenterol 2021 ; 27 (22): 2944-2962
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  • Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury #MMPMID34168400
  • Zhu DD; Tan XM; Lu LQ; Yu SJ; Jian RL; Liang XF; Liao YX; Fan W; Barbier-Torres L; Yang A; Yang HP; Liu T
  • World J Gastroenterol 2021[Jun]; 27 (22): 2944-2962 PMID34168400show ga
  • Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.
  • |*COVID-19/pathology[MESH]
  • |*Inflammation Mediators/metabolism[MESH]
  • |*NF-E2-Related Factor 2/metabolism[MESH]
  • |Humans[MESH]
  • |Liver Diseases/*virology[MESH]
  • |Liver/metabolism/pathology[MESH]
  • |Oxidative Stress[MESH]
  • |SARS-CoV-2[MESH]


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