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10.1038/s41467-021-22785-x http://scihub22266oqcxt.onion/10.1038/s41467-021-22785-x 34168138!8225788!34168138     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34168138&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34168138.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2021 ; 12 (1): 3917 Nephropedia Template TP {{tp|p=34168138|t=2021. The architecture of the SARS-CoV-2 RNA genome inside virion |pdf=|usr=}}{{34168138}} gab.com Text The architecture of the SARS-CoV-2 RNA genome inside virion JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34168138 #FOAvip SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA in situ conformation sequencing technology, named vRIC-seq, for probing viral RNA genome structure unbiasedly. Using vRIC-seq data, we reconstruct the tertiary structure of the SARS-CoV-2 genome and reveal a surprisingly "unentangled globule" conformation. We uncover many long-range duplexes and higher-order junctions, both of which are under purifying selections and contribute to the sequential package of the SARS-CoV-2 genome. Unexpectedly, the D614G and the other two accompanying mutations may remodel duplexes into more stable forms. Lastly, the structure-guided design of potent small interfering RNAs can obliterate the SARS-CoV-2 in Vero cells. Overall, our work provides a framework for studying the genome structure, function, and dynamics of emerging deadly RNA viruses. Twit Text FOAVip The architecture of the SARS-CoV-2 RNA genome inside virion ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34168138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34168138 #FOAvip English Wikipedia <ref>{{Cite pmid|34168138}}</ref> The architecture of the SARS-CoV-2 RNA genome inside virion #MMPMID34168138 Cao C; Cai Z; Xiao X; Rao J; Chen J; Hu N; Yang M; Xing X; Wang Y; Li M; Zhou B; Wang X; Wang J; Xue Y Nat Commun 2021[Jun]; 12 (1): 3917 PMID34168138show ga SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA in situ conformation sequencing technology, named vRIC-seq, for probing viral RNA genome structure unbiasedly. Using vRIC-seq data, we reconstruct the tertiary structure of the SARS-CoV-2 genome and reveal a surprisingly "unentangled globule" conformation. We uncover many long-range duplexes and higher-order junctions, both of which are under purifying selections and contribute to the sequential package of the SARS-CoV-2 genome. Unexpectedly, the D614G and the other two accompanying mutations may remodel duplexes into more stable forms. Lastly, the structure-guided design of potent small interfering RNAs can obliterate the SARS-CoV-2 in Vero cells. Overall, our work provides a framework for studying the genome structure, function, and dynamics of emerging deadly RNA viruses. |Animals[MESH] |COVID-19/genetics/*pathology/virology[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Genome, Viral[MESH] |Humans[MESH] |Nucleic Acid Conformation[MESH] |RNA, Viral/*chemistry/genetics[MESH] |SARS-CoV-2/*genetics/isolation & purification/pathogenicity[MESH] |Sequence Analysis, RNA/*methods[MESH]The architecture of the SARS-CoV-2 RNA genome inside virion (epmc).pdf DeepDyve Pubget Overpricing