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10.1371/journal.pone.0253089 http://scihub22266oqcxt.onion/10.1371/journal.pone.0253089 34166398!8224853!34166398     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34166398&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (6): e0253089 Nephropedia Template TP {{tp|p=34166398|t=2021. SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms |pdf=|usr=}}{{34166398}} gab.com Text SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34166398 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating global pandemic, infecting over 43 million people and claiming over 1 million lives, with these numbers increasing daily. Therefore, there is urgent need to understand the molecular mechanisms governing SARS-CoV-2 pathogenesis, immune evasion, and disease progression. Here, we show that SARS-CoV-2 can block IRF3 and NF-kappaB activation early during virus infection. We also identify that the SARS-CoV-2 viral proteins NSP1 and NSP13 can block interferon activation via distinct mechanisms. NSP1 antagonizes interferon signaling by suppressing host mRNA translation, while NSP13 downregulates interferon and NF-kappaB promoter signaling by limiting TBK1 and IRF3 activation, as phospho-TBK1 and phospho-IRF3 protein levels are reduced with increasing levels of NSP13 protein expression. NSP13 can also reduce NF-kappaB activation by both limiting NF-kappaB phosphorylation and nuclear translocation. Last, we also show that NSP13 binds to TBK1 and downregulates IFIT1 protein expression. Collectively, these data illustrate that SARS-CoV-2 bypasses multiple innate immune activation pathways through distinct mechanisms. Twit Text FOAVip SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34166398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34166398 #FOAvip English Wikipedia <ref>{{Cite pmid|34166398}}</ref> SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms #MMPMID34166398 Vazquez C; Swanson SE; Negatu SG; Dittmar M; Miller J; Ramage HR; Cherry S; Jurado KA PLoS One 2021[]; 16 (6): e0253089 PMID34166398show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating global pandemic, infecting over 43 million people and claiming over 1 million lives, with these numbers increasing daily. Therefore, there is urgent need to understand the molecular mechanisms governing SARS-CoV-2 pathogenesis, immune evasion, and disease progression. Here, we show that SARS-CoV-2 can block IRF3 and NF-kappaB activation early during virus infection. We also identify that the SARS-CoV-2 viral proteins NSP1 and NSP13 can block interferon activation via distinct mechanisms. NSP1 antagonizes interferon signaling by suppressing host mRNA translation, while NSP13 downregulates interferon and NF-kappaB promoter signaling by limiting TBK1 and IRF3 activation, as phospho-TBK1 and phospho-IRF3 protein levels are reduced with increasing levels of NSP13 protein expression. NSP13 can also reduce NF-kappaB activation by both limiting NF-kappaB phosphorylation and nuclear translocation. Last, we also show that NSP13 binds to TBK1 and downregulates IFIT1 protein expression. Collectively, these data illustrate that SARS-CoV-2 bypasses multiple innate immune activation pathways through distinct mechanisms. |Active Transport, Cell Nucleus/genetics/immunology[MESH] |Adaptor Proteins, Signal Transducing/genetics/*immunology[MESH] |COVID-19/genetics/*immunology[MESH] |Cell Nucleus/genetics/*immunology[MESH] |HeLa Cells[MESH] |Humans[MESH] |Interferon Regulatory Factor-3/genetics/*immunology[MESH] |NF-kappa B/genetics/immunology[MESH] |Phosphorylation/genetics/immunology[MESH] |Protein Serine-Threonine Kinases/genetics/immunology[MESH] |RNA-Binding Proteins/genetics/*immunology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Signal Transduction/genetics/*immunology[MESH]SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation(epmc).pdf DeepDyve Pubget Overpricing