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10.1172/jci.insight.150111 http://scihub22266oqcxt.onion/10.1172/jci.insight.150111 34166229!8410057!34166229     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (15): ä Nephropedia Template TP {{tp|p=34166229|t=2021. Autoantibodies stabilize neutrophil extracellular traps in COVID-19 |pdf=|usr=}}{{34166229}} gab.com Text Autoantibodies stabilize neutrophil extracellular traps in COVID-19 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34166229 #FOAvip The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe presentations of COVID-19. At the same time, a variety of functional autoantibodies have been observed in individuals with severe COVID-19, where they likely contribute to immunopathology. Here, we aimed to determine the extent to which autoantibodies might target NETs in COVID-19 and, if detected, to elucidate their potential functions and clinical associations. We measured anti-NET antibodies in 328 individuals hospitalized with COVID-19 alongside 48 healthy controls. We found high anti-NET activity in the IgG and IgM fractions of 27% and 60% of patients, respectively. There was a strong correlation between anti-NET IgG and anti-NET IgM. Both anti-NET IgG and anti-NET IgM tracked with high levels of circulating NETs, impaired oxygenation efficiency, and high circulating D-dimer. Furthermore, patients who required mechanical ventilation had a greater burden of anti-NET antibodies than did those not requiring oxygen supplementation. Levels of anti-NET IgG (and, to a lesser extent, anti-NET IgM) demonstrated an inverse correlation with the efficiency of NET degradation by COVID-19 sera. Furthermore, purified IgG from COVID-19 sera with high levels of anti-NET antibodies impaired the ability of healthy control serum to degrade NETs. In summary, many individuals hospitalized with COVID-19 have anti-NET antibodies, which likely impair NET clearance and may potentiate SARS-CoV-2-mediated thromboinflammation. Twit Text FOAVip Autoantibodies stabilize neutrophil extracellular traps in COVID-19 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34166229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34166229 #FOAvip English Wikipedia <ref>{{Cite pmid|34166229}}</ref> Autoantibodies stabilize neutrophil extracellular traps in COVID-19 #MMPMID34166229 Zuo Y; Yalavarthi S; Navaz SA; Hoy CK; Harbaugh A; Gockman K; Zuo M; Madison JA; Shi H; Kanthi Y; Knight JS JCI Insight 2021[Aug]; 6 (15): ä PMID34166229show ga The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe presentations of COVID-19. At the same time, a variety of functional autoantibodies have been observed in individuals with severe COVID-19, where they likely contribute to immunopathology. Here, we aimed to determine the extent to which autoantibodies might target NETs in COVID-19 and, if detected, to elucidate their potential functions and clinical associations. We measured anti-NET antibodies in 328 individuals hospitalized with COVID-19 alongside 48 healthy controls. We found high anti-NET activity in the IgG and IgM fractions of 27% and 60% of patients, respectively. There was a strong correlation between anti-NET IgG and anti-NET IgM. Both anti-NET IgG and anti-NET IgM tracked with high levels of circulating NETs, impaired oxygenation efficiency, and high circulating D-dimer. Furthermore, patients who required mechanical ventilation had a greater burden of anti-NET antibodies than did those not requiring oxygen supplementation. Levels of anti-NET IgG (and, to a lesser extent, anti-NET IgM) demonstrated an inverse correlation with the efficiency of NET degradation by COVID-19 sera. Furthermore, purified IgG from COVID-19 sera with high levels of anti-NET antibodies impaired the ability of healthy control serum to degrade NETs. In summary, many individuals hospitalized with COVID-19 have anti-NET antibodies, which likely impair NET clearance and may potentiate SARS-CoV-2-mediated thromboinflammation. |Adolescent[MESH] |Adult[MESH] |Autoantibodies/blood/*immunology[MESH] |COVID-19/blood/*immunology[MESH] |Extracellular Traps/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Immunoglobulin M/blood/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/immunology[MESH] |SARS-CoV-2/*immunology[MESH]Autoantibodies stabilize neutrophil extracellular traps in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing