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suck abstract from ncbi


10.1007/s10072-021-05409-6

http://scihub22266oqcxt.onion/10.1007/s10072-021-05409-6
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suck abstract from ncbi

pmid34165650      Neurol+Sci 2021 ; 42 (9): 3533-3535
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  • MS and COVID-19 challenge: asymptomatic COVID-19 infection during treatment with cladribine #MMPMID34165650
  • Seferoglu M; Ethemoglu O; Turan OF; Siva A
  • Neurol Sci 2021[Sep]; 42 (9): 3533-3535 PMID34165650show ga
  • BACKGROUND: The use of disease-modifying therapies (DMTs) in people with multiple sclerosis (pwMS) may affect COVID-19 infection outcomes due to DMTs' immunomodulatory and immunosuppressive effects on immune response. The yet unknown issues are both the early response to the infection, as well as the post-infection development of immunity against the virus under these treatments due to their interaction with the immune system. METHODS: We report two asymptomatic cases of COVID-19 in patients with relapsing-remitting multiple sclerosis (RRMS) shortly after starting cladribine therapy, both developed anti-SARS-CoV-2 antibody response. RESULTS: Patients with MS who are under newly initiated treatment with cladribine tablets may experience an asymptomatic COVID-19 infection and they may develop immunity against SARS-CoV-2. CONCLUSION: These observations raise the probability that DMTs with immunosuppressive effects, such as cladribine, may be considered as a treatment option for selected MS patients with high disease activity during the COVID-19 pandemic.
  • |*COVID-19[MESH]
  • |*Multiple Sclerosis, Relapsing-Remitting/drug therapy[MESH]
  • |*Multiple Sclerosis/drug therapy/epidemiology[MESH]
  • |Cladribine/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Pandemics[MESH]


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