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10.1186/s41687-021-00323-z

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suck abstract from ncbi


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pmid34165646      J+Patient+Rep+Outcomes 2021 ; 5 (1): 48
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  • Crohn s disease and ulcerative colitis patient-reported outcomes signs and symptoms for the remote management of inflammatory bowel disease during the COVID-19 pandemic #MMPMID34165646
  • Pinto S; Loddo E; Paba S; Favale A; Chicco F; Onali S; Usai P; Fantini MC
  • J Patient Rep Outcomes 2021[Jun]; 5 (1): 48 PMID34165646show ga
  • BACKGROUND AND AIMS: The COVID-19 pandemic has led to a deep reorganization of hospital services including inflammatory bowel disease (IBD) units. In this situation, conversion of in-person routine follow-up visits into phone consultations might be necessary. Here we explored the feasibility of using the validated Crohn's Disease (CD) or Ulcerative Colitis (UC) Patient-Reported Outcomes Signs and Symptoms (CD- and UC-PRO/SS) to collect data about abdominal symptoms (abdominal/S) and bowel signs and symptoms (bowel/SS) remotely. METHODS: CD- and UC-PRO/SS were collected during phone consultations and compared among patients with active and inactive disease. The effectiveness of therapeutic intervention in patients with active disease was assessed by PRO/SS variation. RESULTS: Twenty-one CD and 56 UC patients were evaluated by phone. Six (28.6%) CD and 15 (26.8%) UC patients were considered to have active disease. In CD the bowel/SS but not the abdominal/S module was significantly higher in active patients (mean bowel/SS 2.50 [SE +/- 0.44] active vs 0.76 [SE +/- 0.18] remission, p = 0.008, AUC 0.87; mean abdominal/S 1.11 [SE +/- 0.38] active vs 0.24 [SE +/- 0.13] remission, p = 0.066). UC-PRO/SS measures were significantly higher in active patients as compared to patients in remission (median bowel/SS 1.63 [SE +/- 0.24] active vs 0.33 [SE +/- 0.04] remission; p < 0.0001, AUC 0.91; mean abdominal/S 1.03 [SE +/- 0.24] vs 0.37 [SE +/- 0.12]; p = 0.009, AUC 0.71). Therapy was escalated in 12 patients (3 CD and 9 UC) due to disease relapse. Therapy escalation resulted in the reduction of PRO/SS as evaluated at the subsequent phone consultation. CONCLUSIONS: PRO/SS might represent a feasible tool to evaluate disease activity and therapy outcome in IBD patients during periods of limited access to outpatient clinics.
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