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10.1111/tan.14349 http://scihub22266oqcxt.onion/10.1111/tan.14349 34165257!8446943!34165257     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       HLA 2021 ; 98 (2): 122-131 Nephropedia Template TP {{tp|p=34165257|t=2021. HLA-A homozygosis is associated with susceptibility to COVID-19 |pdf=|usr=}}{{34165257}} gab.com Text HLA-A homozygosis is associated with susceptibility to COVID-19 JO: HLA http://www.kidney.de/pget.php?&tw=1&pmid=34165257 #FOAvip The purpose of this single center retrospective study was to investigate the relationship between HLA and ABO polymorphisms and COVID-19 susceptibility and severity in kidney transplant recipients. It included 720 recipients who had COVID-19 and 1680 controls composed by recipients in follow-up who did not contact the transplantation center for COVID-19 symptoms, up to the moment of their inclusion in the study. HLA-A, -B, and -DRB1 allele groups and ABO frequencies were compared between recipients with COVID-19 (all cases, or separately mild/moderate and severe disease) and controls. The HLA association study was conducted in two case-control series and only associations that showed a p-value <0.05 in both series were considered. No HLA association regarding COVID-19 occurrence or severity met this criterion. Homozygosity at HLA-A locus was associated with COVID-19 susceptibility (odds ratio 1.4) but not severity. Blood groups A and O were associated with susceptibility and resistance to COVID-19, respectively. COVID-19 severity was associated only with older age and cardiac disease, in a multivariate analysis. We conclude that an influence of HLA on COVID-19 susceptibility is supported by the association with homozygosity at HLA-A locus but that there is no evidence for a role of any particular HLA-A, -B, or -DRB1 polymorphism. Thus, we suggest that what matters is the overall capability of an individual's HLA molecules to present SARS-CoV-2 peptides to T cells, a factor that might have a great influence on the breadth of the immune response. Twit Text FOAVip HLA-A homozygosis is associated with susceptibility to COVID-19 ????HLA http://www.kidney.de/pget.php?&tw=1&pmid=34165257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34165257 #FOAvip English Wikipedia <ref>{{Cite pmid|34165257}}</ref> HLA-A homozygosis is associated with susceptibility to COVID-19 #MMPMID34165257 De Marco R; Faria TC; Mine KL; Cristelli M; Medina-Pestana JO; Tedesco-Silva H; Gerbase-DeLima M HLA 2021[Aug]; 98 (2): 122-131 PMID34165257show ga The purpose of this single center retrospective study was to investigate the relationship between HLA and ABO polymorphisms and COVID-19 susceptibility and severity in kidney transplant recipients. It included 720 recipients who had COVID-19 and 1680 controls composed by recipients in follow-up who did not contact the transplantation center for COVID-19 symptoms, up to the moment of their inclusion in the study. HLA-A, -B, and -DRB1 allele groups and ABO frequencies were compared between recipients with COVID-19 (all cases, or separately mild/moderate and severe disease) and controls. The HLA association study was conducted in two case-control series and only associations that showed a p-value <0.05 in both series were considered. No HLA association regarding COVID-19 occurrence or severity met this criterion. Homozygosity at HLA-A locus was associated with COVID-19 susceptibility (odds ratio 1.4) but not severity. Blood groups A and O were associated with susceptibility and resistance to COVID-19, respectively. COVID-19 severity was associated only with older age and cardiac disease, in a multivariate analysis. We conclude that an influence of HLA on COVID-19 susceptibility is supported by the association with homozygosity at HLA-A locus but that there is no evidence for a role of any particular HLA-A, -B, or -DRB1 polymorphism. Thus, we suggest that what matters is the overall capability of an individual's HLA molecules to present SARS-CoV-2 peptides to T cells, a factor that might have a great influence on the breadth of the immune response. |*COVID-19[MESH] |Aged[MESH] |Alleles[MESH] |Gene Frequency[MESH] |Genetic Predisposition to Disease[MESH] |HLA-A Antigens/genetics[MESH] |HLA-DRB1 Chains/genetics[MESH] |Humans[MESH] |Retrospective Studies[MESH]HLA-A homozygosis is associated with susceptibility to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing