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10.1039/d0sc05330a http://scihub22266oqcxt.onion/10.1039/d0sc05330a 34163908!8179027!34163908     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Sci 2020 ; 12 (4): 1451-1457 Nephropedia Template TP {{tp|p=34163908|t=2020. Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling |pdf=|usr=}}{{34163908}} gab.com Text Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34163908 #FOAvip Probing the conformational and functional hotspot sites within aqueous native protein complexes is still a challenging task. Herein, a mass spectrometry (MS)-based two-step isotope labeling-lysine reactivity profiling (TILLRP) strategy is developed to quantify the reactivities of lysine residues and probe the molecular details of protein-protein interactions as well as evaluate the conformational interventions by small-molecule active compounds. The hotspot lysine sites that are crucial to the SARS-CoV-2 S1-ACE2 combination could be successfully probed, such as S1 Lys(417) and Lys(444). Significant alteration of the reactivities of lysine residues at the interaction interface of S1-RBD Lys(386)-Lys(462) was observed during the formation of complexes, which might be utilized as indicators for investigating the S1-ACE2 dynamic recognition and intervention at the molecular level in high throughput. Twit Text FOAVip Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34163908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34163908 #FOAvip English Wikipedia <ref>{{Cite pmid|34163908}}</ref> Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling #MMPMID34163908 Liu Z; Zhang W; Sun B; Ma Y; He M; Pan Y; Wang F Chem Sci 2020[Nov]; 12 (4): 1451-1457 PMID34163908show ga Probing the conformational and functional hotspot sites within aqueous native protein complexes is still a challenging task. Herein, a mass spectrometry (MS)-based two-step isotope labeling-lysine reactivity profiling (TILLRP) strategy is developed to quantify the reactivities of lysine residues and probe the molecular details of protein-protein interactions as well as evaluate the conformational interventions by small-molecule active compounds. The hotspot lysine sites that are crucial to the SARS-CoV-2 S1-ACE2 combination could be successfully probed, such as S1 Lys(417) and Lys(444). Significant alteration of the reactivities of lysine residues at the interaction interface of S1-RBD Lys(386)-Lys(462) was observed during the formation of complexes, which might be utilized as indicators for investigating the S1-ACE2 dynamic recognition and intervention at the molecular level in high throughput. äProbing conformational hotspots for the recognition and intervention o(epmc).pdf DeepDyve Pubget Overpricing