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10.1039/d0sc05447j http://scihub22266oqcxt.onion/10.1039/d0sc05447j 34163793!8179002!34163793     free     free     free       Chem+Sci 2020 ; 12 (2): 626-631 Nephropedia Template TP {{tp|p=34163793|t=2020. Inhibitors of thiol-mediated uptake |pdf=|usr=}}{{34163793}} gab.com Text Inhibitors of thiol-mediated uptake JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34163793 #FOAvip Ellman's reagent has caused substantial confusion and concern as a probe for thiol-mediated uptake because it is the only established inhibitor available but works neither efficiently nor reliably. Here we use fluorescent cyclic oligochalcogenides that enter cells by thiol-mediated uptake to systematically screen for more potent inhibitors, including epidithiodiketopiperazines, benzopolysulfanes, disulfide-bridged gamma-turned peptides, heteroaromatic sulfones and cyclic thiosulfonates, thiosulfinates and disulfides. With nanomolar activity, the best inhibitors identified are more than 5000 times better than Ellman's reagent. Different activities found with different reporters reveal thiol-mediated uptake as a complex multitarget process. Preliminary results on the inhibition of the cellular uptake of pseudo-lentivectors expressing SARS-CoV-2 spike protein do not exclude potential of efficient inhibitors of thiol-mediated uptake for the development of new antivirals. Twit Text FOAVip Inhibitors of thiol-mediated uptake ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34163793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34163793 #FOAvip English Wikipedia <ref>{{Cite pmid|34163793}}</ref> Inhibitors of thiol-mediated uptake #MMPMID34163793 Cheng Y; Pham AT; Kato T; Lim B; Moreau D; Lopez-Andarias J; Zong L; Sakai N; Matile S Chem Sci 2020[Nov]; 12 (2): 626-631 PMID34163793show ga Ellman's reagent has caused substantial confusion and concern as a probe for thiol-mediated uptake because it is the only established inhibitor available but works neither efficiently nor reliably. Here we use fluorescent cyclic oligochalcogenides that enter cells by thiol-mediated uptake to systematically screen for more potent inhibitors, including epidithiodiketopiperazines, benzopolysulfanes, disulfide-bridged gamma-turned peptides, heteroaromatic sulfones and cyclic thiosulfonates, thiosulfinates and disulfides. With nanomolar activity, the best inhibitors identified are more than 5000 times better than Ellman's reagent. Different activities found with different reporters reveal thiol-mediated uptake as a complex multitarget process. Preliminary results on the inhibition of the cellular uptake of pseudo-lentivectors expressing SARS-CoV-2 spike protein do not exclude potential of efficient inhibitors of thiol-mediated uptake for the development of new antivirals. äInhibitors of thiol-mediated uptake (epmc).pdf DeepDyve Pubget Overpricing