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10.1016/j.diagmicrobio.2021.115392 http://scihub22266oqcxt.onion/10.1016/j.diagmicrobio.2021.115392 34161880!8059257!34161880     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagn+Microbiol+Infect+Dis 2021 ; 101 (2): 115392 Nephropedia Template TP {{tp|p=34161880|t=2021. Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort |pdf=|usr=}}{{34161880}} gab.com Text Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort JO: Diagn Microbiol Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34161880 #FOAvip Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. We reinforce previous findings on limited sensitivity of PCR testing, and solidify this fact by statistically utilizing a firm basis of multiple tests per individual. We integrate stratifications with respect to several patient characteristics such as severity of disease and time since onset of symptoms. Bayesian statistical modelling was used to retrospectively determine the sensitivity of RT-PCR using SARS-CoV-2 serology in 644 COVID-19-suspected patients with varying degrees of disease severity and duration. The sensitivity of RT-PCR ranged between 80% - 95%; increasing with disease severity, it decreased rapidly over time in mild COVID-19 cases. Negative URT RT-PCR results should be interpreted in the context of clinical characteristics, especially with regard to containment of viral transmission based on 'test, trace and isolate'. Keywords: SARS-CoV-2, RT-PCR, serology, sensitivity, public health. Twit Text FOAVip Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort ????Diagn Microbiol Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34161880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34161880 #FOAvip English Wikipedia <ref>{{Cite pmid|34161880}}</ref> Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort #MMPMID34161880 Bergmans BJM; Reusken CBEM; van Oudheusden AJG; Godeke GJ; Bonacic Marinovic AA; de Vries E; Kluiters-de Hingh YCM; Vingerhoets R; Berrevoets MAH; Verweij JJ; Nieman AE; Reimerink J; Murk JL; Swart A Diagn Microbiol Infect Dis 2021[Oct]; 101 (2): 115392 PMID34161880show ga Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. We reinforce previous findings on limited sensitivity of PCR testing, and solidify this fact by statistically utilizing a firm basis of multiple tests per individual. We integrate stratifications with respect to several patient characteristics such as severity of disease and time since onset of symptoms. Bayesian statistical modelling was used to retrospectively determine the sensitivity of RT-PCR using SARS-CoV-2 serology in 644 COVID-19-suspected patients with varying degrees of disease severity and duration. The sensitivity of RT-PCR ranged between 80% - 95%; increasing with disease severity, it decreased rapidly over time in mild COVID-19 cases. Negative URT RT-PCR results should be interpreted in the context of clinical characteristics, especially with regard to containment of viral transmission based on 'test, trace and isolate'. Keywords: SARS-CoV-2, RT-PCR, serology, sensitivity, public health. |*COVID-19 Nucleic Acid Testing[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Bayes Theorem[MESH] |COVID-19 Serological Testing[MESH] |COVID-19/*diagnosis/prevention & control/transmission[MESH] |Contact Tracing[MESH] |False Negative Reactions[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Netherlands/epidemiology[MESH] |Quarantine[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/genetics/immunology/*isolation & purification[MESH] |Sensitivity and Specificity[MESH]Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivit(epmc).pdf DeepDyve Pubget Overpricing