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10.1016/j.cell.2021.06.002 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.06.002 34161776!8179113!34161776     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (15): 3949-3961.e11 Nephropedia Template TP {{tp|p=34161776|t=2021. The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies |pdf=|usr=}}{{34161776}} gab.com Text The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34161776 #FOAvip Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Our study demonstrates that the combination of non-competing antibodies in REGEN-COV provides protection against all current SARS-CoV-2 variants of concern/interest and also protects against emergence of new variants and their potential seeding into the population in a clinical setting. Twit Text FOAVip The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34161776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34161776 #FOAvip English Wikipedia <ref>{{Cite pmid|34161776}}</ref> The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies #MMPMID34161776 Copin R; Baum A; Wloga E; Pascal KE; Giordano S; Fulton BO; Zhou A; Negron N; Lanza K; Chan N; Coppola A; Chiu J; Ni M; Wei Y; Atwal GS; Hernandez AR; Saotome K; Zhou Y; Franklin MC; Hooper AT; McCarthy S; Hamon S; Hamilton JD; Staples HM; Alfson K; Carrion R Jr; Ali S; Norton T; Somersan-Karakaya S; Sivapalasingam S; Herman GA; Weinreich DM; Lipsich L; Stahl N; Murphy AJ; Yancopoulos GD; Kyratsous CA Cell 2021[Jul]; 184 (15): 3949-3961.e11 PMID34161776show ga Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Our study demonstrates that the combination of non-competing antibodies in REGEN-COV provides protection against all current SARS-CoV-2 variants of concern/interest and also protects against emergence of new variants and their potential seeding into the population in a clinical setting. |Animals[MESH] |Antibodies, Monoclonal/*immunology[MESH] |COVID-19/*immunology/*prevention & control/virology[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Cryoelectron Microscopy[MESH] |Hospitalization[MESH] |Humans[MESH] |Lung/pathology/virology[MESH] |Male[MESH] |Mutation/*genetics[MESH] |Neutralization Tests[MESH] |SARS-CoV-2/*genetics/*immunology[MESH] |Vero Cells[MESH]The monoclonal antibody combination REGEN-COV protects against SARS-Co(epmc).pdf DeepDyve Pubget Overpricing