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Endothelial metabolism in pulmonary vascular homeostasis and acute respiratory distress syndrome #MMPMID34159794
Stevens RP; Paudel SS; Johnson SC; Stevens T; Lee JY
Am J Physiol Lung Cell Mol Physiol 2021[Aug]; 321 (2): L358-L376 PMID34159794show ga
Capillary endothelial cells possess a specialized metabolism necessary to adapt to the unique alveolar-capillary environment. Here, we highlight how endothelial metabolism preserves the integrity of the pulmonary circulation by controlling vascular permeability, defending against oxidative stress, facilitating rapid migration and angiogenesis in response to injury, and regulating the epigenetic landscape of endothelial cells. Recent reports on single-cell RNA-sequencing reveal subpopulations of pulmonary capillary endothelial cells with distinctive reparative capacities, which potentially offer new insight into their metabolic signature. Lastly, we discuss broad implications of pulmonary vascular metabolism on acute respiratory distress syndrome, touching on emerging findings of endotheliitis in coronavirus disease 2019 (COVID-19) lungs.