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10.1093/abbs/gmab088 http://scihub22266oqcxt.onion/10.1093/abbs/gmab088 34159380!ä!34159380 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Biochim+Biophys+Sin+(Shanghai) 2021 ; 53 (9): 1134-1141 Nephropedia Template TP {{tp|p=34159380|t=2021. Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins |pdf=|usr=}}{{34159380}} gab.com Text Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins JO: Acta Biochim Biophys Sin (Shanghai) http://www.kidney.de/pget.php?&tw=1&pmid=34159380 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health threat since December 2019, and there is still no highly effective drug to control the pandemic. To facilitate drug target identification for drug development, studies on molecular mechanisms, such as SARS-CoV-2 protein interactions, are urgently needed. In this study, we focused on Nsp2, a non-structural protein with largely unknown function and mechanism. The interactome of Nsp2 was revealed through the combination of affinity purification mass spectrometry (AP-MS) and stable isotope labeling by amino acids in cell culture (SILAC), and 84 proteins of high-confidence were identified. Gene ontology analysis demonstrated that Nsp2-interacting proteins are involved in several biological processes such as endosome transport and translation. Network analysis generated two clusters, including ribosome assembly and vesicular transport. Bio-layer interferometry (BLI) assay confirmed the bindings between Nsp2- and 4-interacting proteins, i.e. STAU2 (Staufen2), HNRNPLL, ATP6V1B2, and RAP1GDS1 (SmgGDS), which were randomly selected from the list of 84 proteins. Our findings provide insights into the Nsp2-host interplay and indicate that Nsp2 may play important roles in SARS-CoV-2 infection and serve as a potential drug target for anti-SARS-CoV-2 drug development. Twit Text FOAVip Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins ????Acta Biochim Biophys Sin (Shanghai) http://www.kidney.de/pget.php?&tw=1&pmid=34159380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34159380 #FOAvip English Wikipedia <ref>{{Cite pmid|34159380}}</ref> Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins #MMPMID34159380 Zheng YX; Wang L; Kong WS; Chen H; Wang XN; Meng Q; Zhang HN; Guo SJ; Jiang HW; Tao SC Acta Biochim Biophys Sin (Shanghai) 2021[Aug]; 53 (9): 1134-1141 PMID34159380show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health threat since December 2019, and there is still no highly effective drug to control the pandemic. To facilitate drug target identification for drug development, studies on molecular mechanisms, such as SARS-CoV-2 protein interactions, are urgently needed. In this study, we focused on Nsp2, a non-structural protein with largely unknown function and mechanism. The interactome of Nsp2 was revealed through the combination of affinity purification mass spectrometry (AP-MS) and stable isotope labeling by amino acids in cell culture (SILAC), and 84 proteins of high-confidence were identified. Gene ontology analysis demonstrated that Nsp2-interacting proteins are involved in several biological processes such as endosome transport and translation. Network analysis generated two clusters, including ribosome assembly and vesicular transport. Bio-layer interferometry (BLI) assay confirmed the bindings between Nsp2- and 4-interacting proteins, i.e. STAU2 (Staufen2), HNRNPLL, ATP6V1B2, and RAP1GDS1 (SmgGDS), which were randomly selected from the list of 84 proteins. Our findings provide insights into the Nsp2-host interplay and indicate that Nsp2 may play important roles in SARS-CoV-2 infection and serve as a potential drug target for anti-SARS-CoV-2 drug development. |*COVID-19 Drug Treatment[MESH] |Drug Delivery Systems[MESH] |Guanine Nucleotide Exchange Factors/chemistry/metabolism[MESH] |HEK293 Cells[MESH] |Heterogeneous-Nuclear Ribonucleoproteins/chemistry/metabolism[MESH] |Humans[MESH] |Nerve Tissue Proteins/chemistry/metabolism[MESH] |Protein Binding[MESH] |RNA-Binding Proteins/chemistry/metabolism[MESH] |SARS-CoV-2/*chemistry/metabolism[MESH] |Vacuolar Proton-Translocating ATPases/chemistry/metabolism[MESH]Nsp2 has the potential to be a drug target revealed by global identifi(epmc).pdf DeepDyve Pubget Overpricing