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10.1177/11772719211021647

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suck abstract from ncbi


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pmid34158797      Biomark+Insights 2021 ; 16 (ä): 11772719211021647
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  • Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study #MMPMID34158797
  • Tromp K; van der Zee P; Rokx C; van Kampen J; Gommers D; Endeman H
  • Biomark Insights 2021[]; 16 (ä): 11772719211021647 PMID34158797show ga
  • Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.
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